Division of Plastic Surgery, Mayo Clinic, Jacksonville, FL, USA.
Department of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USA.
Breast Dis. 2020;39(3-4):119-126. doi: 10.3233/BD-200439.
Paget's disease of the breast is rare. The National Cancer Database (NCDB) is one of the largest tumor databases in the United States.
We queried the NCDB to identify male and female patients with Paget's disease of the breast who were treated from January 1, 2004, through December 31, 2015. No age limitations were applied. Descriptive statistical analysis and survival analysis were performed.
We analyzed the demographic, disease, and treatment characteristics of 7,191 patients with Paget's disease of the breast. The median (range) age was 64 (20-90) years. Only 2.1% of patients were men, and 85.4% were white. The most common treatment was complete mastectomy (65.3%), followed by partial mastectomy (30.3%). Tumor destruction was performed in 0.1% of patients, and 4.3% of patients did not undergo any surgery. We examined survival in the subset of 6,864 patients who were treated surgically with complete mastectomy or partial mastectomy. The 5-year survival rate after surgery was 82.5% (95% CI, 81.1%-83.9%). Factors associated with shorter survival were older age, black race/ethnicity, higher tumor grade, regional lymph node metastasis, higher cancer stage, metastatic cancer, and larger tumor size.
Paget's disease of the breast usually affects patients older than 60 years, and the most common treatment is complete mastectomy. The 5-year overall survival rate of patients with Paget's disease of the breast is greater than 80% but is lower among older and black people.
乳腺佩吉特病较为罕见。国家癌症数据库（NCDB）是美国最大的肿瘤数据库之一。
我们通过 NCDB 检索了 2004 年 1 月 1 日至 2015 年 12 月 31 日期间接受治疗的男性和女性乳腺佩吉特病患者。未对年龄进行限制。进行了描述性统计分析和生存分析。
我们分析了 7191 例乳腺佩吉特病患者的人口统计学、疾病和治疗特征。中位（范围）年龄为 64（20-90）岁。仅有 2.1%的患者为男性，85.4%为白人。最常见的治疗方法是全乳切除术（65.3%），其次是部分乳房切除术（30.3%）。有 0.1%的患者进行了肿瘤破坏，4.3%的患者未进行任何手术。我们检查了在接受全乳切除术或部分乳房切除术治疗的 6864 例手术患者中生存情况。手术后 5 年的生存率为 82.5%（95%CI，81.1%-83.9%）。与较短生存期相关的因素包括年龄较大、黑种人/西班牙裔、较高的肿瘤分级、区域淋巴结转移、较高的癌症分期、转移性癌症和较大的肿瘤大小。
乳腺佩吉特病通常影响 60 岁以上的患者，最常见的治疗方法是全乳切除术。乳腺佩吉特病患者的 5 年总生存率大于 80%，但在年龄较大和黑人中较低。
