接触质子泵抑制剂与儿童自身免疫性疾病的发生有关。
Exposure to proton pump inhibitors is associated with the development of pediatric autoimmune diseases.
作者信息
Räisänen Laura, Viljakainen Heli, Kolho Kaija-Leena
机构信息
Department of Pediatrics, Tampere University Hospital, Tampere, Finland.
Public Health Research Program, Folkhälsan Research Center, Helsinki, Finland.
出版信息
Front Pediatr. 2023 Mar 27;11:1157547. doi: 10.3389/fped.2023.1157547. eCollection 2023.
Proton pump inhibitors (PPIs) have been associated with decreased gut microbiota diversity. Disrupted gut microbiota composition has been reported in several autoimmune diseases (ADs), such as type 1 diabetes mellitus (DM), autoimmune thyroiditis (AIT), juvenile idiopathic arthritis (JIA), and inflammatory bowel diseases (IBD). We investigated whether PPIs are associated with the development of ADs in children and concluded that PPI exposures could be related to the onset of ADs, especially IBD and potentially AIT as well.
质子泵抑制剂（PPIs）与肠道微生物群多样性降低有关。据报道，在几种自身免疫性疾病（ADs）中，肠道微生物群组成受到破坏，如1型糖尿病（DM）、自身免疫性甲状腺炎（AIT）、幼年特发性关节炎（JIA）和炎症性肠病（IBD）。我们调查了PPIs是否与儿童ADs的发生有关，并得出结论，接触PPIs可能与ADs的发病有关，尤其是IBD，也可能与AIT有关。
Zotero 插件