Bensinger W I, Buckner C D, Clift R A, Slichter S J, Thomas E D
Transplantation. 1986 May;41(5):602-5. doi: 10.1097/00007890-198605000-00010.
We studied the effectiveness of plasma exchange for reversing antiplatelet alloimmunization in 18 patients undergoing marrow transplantation. Patients received one-to-three daily exchanges. Most exchanges occurred during the pretransplant conditioning phase. Overall, eleven of 18 patients had a beneficial response to plasma exchange, defined as an improvement in post-platelet-transfusion increments. More patients responded who had received two or more exchanges. Patients who had lymphocytotoxic antibodies pretransplant were more likely to benefit from the exchange. Our results show that plasma exchange may improve the posttransfusion platelet increments in alloimmunized patients undergoing marrow transplant.
我们研究了血浆置换对18例接受骨髓移植患者逆转抗血小板同种免疫的有效性。患者每天接受1至3次置换。大多数置换发生在移植前预处理阶段。总体而言，18例患者中有11例对血浆置换有有益反应，定义为血小板输注后增量有所改善。接受两次或更多次置换的患者反应更多。移植前有淋巴细胞毒性抗体的患者更有可能从置换中获益。我们的结果表明，血浆置换可能改善接受骨髓移植的同种免疫患者的输血后血小板增量。
