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多发性骨髓瘤浆细胞动力学：使用抗5-溴-2-脱氧尿苷（BrdUrd）单克隆抗体检测BrdUrd掺入DNA进行快速可靠评估。

Multiple myeloma plasma cell kinetics: rapid and reliable evaluation using 5-bromo-2-deoxyuridine (BrdUrd) DNA incorporation detected by an anti-BrdUrd monoclonal antibody.

作者信息

Boccadoro M, Redoglio V, Gavarotti P, Pileri A

出版信息

Tumori. 1986 Apr 30;72(2):135-7. doi: 10.1177/030089168607200203.

DOI:10.1177/030089168607200203
PMID:3705185
Abstract

In 19 patients with monoclonal gammopathy, plasma cell proliferative activity was evaluated using 5-bromo-2-deoxyuridine (BrdUrd) incorporation, as revealed by an anti-BrdUrd monoclonal antibody. A simultaneous standard labelled thymidine incorporation was carried out in all patients as reference test. The BrdUrd method was confirmed as a reliable test and is recommended for routine clinical application in monoclonal gammopathies.

摘要

在19例单克隆丙种球蛋白病患者中，使用5-溴-2-脱氧尿苷（BrdUrd）掺入法评估浆细胞增殖活性，通过抗BrdUrd单克隆抗体检测。所有患者同时进行标准标记的胸腺嘧啶核苷掺入作为参考试验。BrdUrd方法被确认为可靠的检测方法，推荐用于单克隆丙种球蛋白病的常规临床应用。

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Multiple myeloma plasma cell kinetics: rapid and reliable evaluation using 5-bromo-2-deoxyuridine (BrdUrd) DNA incorporation detected by an anti-BrdUrd monoclonal antibody.多发性骨髓瘤浆细胞动力学：使用抗5-溴-2-脱氧尿苷（BrdUrd）单克隆抗体检测BrdUrd掺入DNA进行快速可靠评估。
Tumori. 1986 Apr 30;72(2):135-7. doi: 10.1177/030089168607200203.
2
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引用本文的文献

1
Bromodeoxyuridine: a diagnostic tool in biology and medicine, Part II: Oncology, chemotherapy and carcinogenesis.溴脱氧尿苷：生物学与医学中的诊断工具，第二部分：肿瘤学、化疗与致癌作用
Histochem J. 1995 Dec;27(12):923-64.
2
In situ demonstration of tissue proliferative activity using anti-bromo-deoxyuridine monoclonal antibody.使用抗溴脱氧尿苷单克隆抗体对组织增殖活性进行原位检测。
J Clin Pathol. 1989 Aug;42(8):820-6. doi: 10.1136/jcp.42.8.820.