大汗腺化生在乳房下象限分布不均且显著集中。

Uneven distribution and significant concentration of apocrine metaplasia in lower breast quadrants.

作者信息

Benigni G, Squartini F

出版信息

Tumori. 1986 Apr 30;72(2):179-82. doi: 10.1177/030089168607200210.

DOI:10.1177/030089168607200210

Abstract

Two hundred human breasts removed for clinical cancer by radical mastectomy were analyzed to determine whether apocrine metaplasia and apocrine cysts have predilective sites in the four mammary quadrants. One block of tissue randomly removed for each quadrant was examined in one or more histologic sections. The results showed a concentration of apocrine metaplasia and apocrine cysts in the lower mammary quadrants (17.5% versus 8.2%), which is highly significant (chi 2 = 15.25; P less than 0.001). The different distribution between breast cancer (showing predilection for the upper quadrants) and apocrine metaplasia is emphasized, together with the highly significant association between apocrine metaplasia and breast cancer. Based on these data, the usefulness of the clinical detection of cysts in the lower mammary quadrants and needle aspiration of their fluid for the morphologic or biochemical diagnosis of apocrine metaplasia in the screening and management of women at risk is suggested.

摘要

对200例因临床确诊为癌症而接受根治性乳房切除术切除的人类乳房进行分析，以确定大汗腺化生和大汗腺囊肿在四个乳腺象限中是否有好发部位。每个象限随机切除一块组织，在一个或多个组织学切片中进行检查。结果显示，大汗腺化生和大汗腺囊肿集中在乳腺下象限（17.5%对8.2%），差异具有高度显著性（卡方=15.25；P<0.001）。强调了乳腺癌（好发于上象限）与大汗腺化生之间不同的分布情况，以及大汗腺化生与乳腺癌之间高度显著的关联。基于这些数据，建议在对有风险的女性进行筛查和管理时，临床上检测乳腺下象限囊肿并对其液体进行针吸，用于大汗腺化生的形态学或生化诊断。