Department of Rehabilitation Medicine, Yantaishan Hospital, Yantai, China.
J Pak Med Assoc. 2023 Apr;73(4):879-881. doi: 10.47391/JPMA.6487.
The purpose of this study was to compare the efficacy of Trazodone hydrochloride tablets alone and in combination with press-needles in the treatment of post-stroke depression. One hundred and four post-stroke depression patients, admitted to Yantaishan Hospital, China, from August 2019 to June 2021, were randomly divided in two groups: Group A (n=52) and Group B (n=52). Group A was given oral Trazodone hydrochloride tablets, while Group B was treated with press-needle and Trazodone hydrochloride tablets. Post treatment assessment revealed that after treatment, National Institutes of Health Stroke Scale scores, Hamilton Depression Rating Scale scores, serum 5-hydroxytryptamine and brain-derived neurotrophic factor levels of Group B were lower than those of Group A (all p<0.001). Treatment efficiency of Group B was higher than that of Group A (p=0.014). Compared with Trazodone hydrochloride tablets alone, Trazodone hydrochloride tablets combined with press-needles may reduce neurological impairment and depressive mood in post-stroke depression patients more effectively. It can be because the combination better promotes the increase of 5-hydroxytryptamine and brain-derived neurotrophic factor.
本研究旨在比较盐酸曲唑酮片单独应用与联合压针治疗脑卒中后抑郁的疗效。选择 2019 年 8 月至 2021 年 6 月中国烟台山医院收治的 104 例脑卒中后抑郁患者，随机分为两组：A 组（n=52）和 B 组（n=52）。A 组给予盐酸曲唑酮片口服，B 组采用压针联合盐酸曲唑酮片治疗。治疗后评估发现，B 组治疗后美国国立卫生研究院卒中量表评分、汉密尔顿抑郁量表评分、血清 5-羟色胺和脑源性神经营养因子水平均低于 A 组（均 P<0.001）。B 组的治疗有效率高于 A 组（P=0.014）。与盐酸曲唑酮片单独治疗相比，盐酸曲唑酮片联合压针治疗可能更有效地减轻脑卒中后抑郁患者的神经功能缺损和抑郁情绪，这可能是因为联合治疗更好地促进了 5-羟色胺和脑源性神经营养因子的增加。
