Shanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, Shanxi 030001, P.R. China.
Int J Mol Med. 2023 Jun;51(6). doi: 10.3892/ijmm.2023.5248. Epub 2023 Apr 13.
Head and neck squamous cell carcinoma (HNSCC), a common malignancy of the head and neck, is associated with a rapid progression, a high mortality rate and unsatisfactory curative effects. The treatment efficacy is unsatisfactory due to chemotherapeutic drug resistance, the lack of ideal therapeutic agents, as well as the absence of clinical prognostic models. Thus, the identification of novel potential therapeutic targets for its diagnosis and treatment is vital. Ferroptosis is an iron‑dependent regulatory cell death mode different from traditional cell death modes, such as apoptosis and autophagy, and has notable therapeutic potential in cancer treatment. The study of ferroptosis in HNSCC is expected to solve this bottleneck problem. In the present review, the findings, characteristics and regulatory mechanisms of ferroptosis are summarized, with emphasis on the factors and drugs that regulate ferroptosis in HNSCC, in order to provide theoretical basis for the targeted therapy of ferroptosis in HNSCC.
头颈部鳞状细胞癌（HNSCC）是一种常见的头颈部恶性肿瘤，其具有快速进展、高死亡率和不理想的治疗效果等特点。由于化疗药物耐药性、缺乏理想的治疗药物以及缺乏临床预后模型，治疗效果并不令人满意。因此，鉴定新的潜在治疗靶点用于其诊断和治疗至关重要。铁死亡是一种不同于传统细胞死亡方式（如凋亡和自噬）的铁依赖性调节性细胞死亡方式，在癌症治疗中具有显著的治疗潜力。研究 HNSCC 中的铁死亡有望解决这一瓶颈问题。本综述总结了铁死亡的研究发现、特征和调控机制，重点介绍了调控 HNSCC 中铁死亡的因素和药物，以期为 HNSCC 的铁死亡靶向治疗提供理论依据。
