文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

一种新的铁死亡相关基因签名，用于预测头颈部鳞状细胞癌患者的预后。

A Novel Ferroptosis-Related Gene Signature to Predict Prognosis in Patients with Head and Neck Squamous Cell Carcinoma.

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000 Guizhou Province, China.

出版信息

Dis Markers. 2021 Nov 22;2021:5759927. doi: 10.1155/2021/5759927. eCollection 2021.

DOI:10.1155/2021/5759927
PMID:34853622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8629675/
Abstract

The clinical TNM staging system is currently used to evaluate the prognosis of head and neck squamous cell carcinoma (HNSCC). The 5-year survival rate for patients with HNSCC is less than 50%, which is attributed to the lack of reliable prognostic biomarkers. Ferroptosis-related genes (FRGs) regulate cancer initiation and progression. Therefore, we analyzed the correlation between FRGs and the clinical outcomes of patients with . A typical prognostic model of FRGs for HNSCC was constructed using bioinformatics tools and data from public databases, including The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and GeneCards. The model was generated based on the following six FRGs: , , , , , and . The accuracy of model prediction was analyzed systematically. The overall survival (OS) of the high-risk group was significantly lower than that of the low-risk group. The AUC for 1-year, 3-year, and 5-year survival were 0.645, 0.721, and 0.737, respectively, in the training set (TCGA cohort) and 0.726, 0.620, and 0.584, respectively, in the validation set (GSE65858). The multivariate Cox regression analysis revealed that the risk score was an independent prognostic factor for HNSCC. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses revealed that six FRGs were enriched in the ferroptosis pathway. A novel FRG prognostic signature model was established for HNSCC. The findings of this study reveal that FRGs are potential biomarkers for HNSCC.

摘要

目前，临床 TNM 分期系统用于评估头颈部鳞状细胞癌（HNSCC）的预后。HNSCC 患者的 5 年生存率低于 50%，这归因于缺乏可靠的预后生物标志物。铁死亡相关基因（FRGs）调节癌症的发生和进展。因此，我们分析了 FRGs 与. 患者临床结局的相关性。使用生物信息学工具和来自公共数据库（包括癌症基因组图谱（TCGA）、基因表达综合数据库（GEO）和基因卡片）的数据构建了用于预测 HNSCC 的 FRGs 典型预后模型。该模型基于以下六个 FRGs 构建： ， ， ， ， ， 。系统分析了模型预测的准确性。高危组的总体生存率（OS）明显低于低危组。在训练集（TCGA 队列）中，1 年、3 年和 5 年的 AUC 分别为 0.645、0.721 和 0.737，在验证集（GSE65858）中分别为 0.726、0.620 和 0.584。多变量 Cox 回归分析表明，风险评分是 HNSCC 的独立预后因素。基因本体论（GO）和京都基因与基因组百科全书（KEGG）分析表明，六个 FRGs 富集在铁死亡途径中。建立了用于 HNSCC 的新型 FRG 预后签名模型。本研究的结果表明，FRGs 是 HNSCC 的潜在生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/d98cca3deb34/DM2021-5759927.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/de3508c4e95f/DM2021-5759927.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/a2336e28ba0c/DM2021-5759927.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/08dba835aaaa/DM2021-5759927.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/49e5de941809/DM2021-5759927.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/812885d9c21f/DM2021-5759927.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/893c18c434ef/DM2021-5759927.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/876fa0c99aad/DM2021-5759927.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/311bbf449e0f/DM2021-5759927.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/3ab15a1a8dec/DM2021-5759927.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/d98cca3deb34/DM2021-5759927.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/de3508c4e95f/DM2021-5759927.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/a2336e28ba0c/DM2021-5759927.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/08dba835aaaa/DM2021-5759927.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/49e5de941809/DM2021-5759927.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/812885d9c21f/DM2021-5759927.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/893c18c434ef/DM2021-5759927.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/876fa0c99aad/DM2021-5759927.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/311bbf449e0f/DM2021-5759927.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/3ab15a1a8dec/DM2021-5759927.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eab/8629675/d98cca3deb34/DM2021-5759927.010.jpg

相似文献

[1]
A Novel Ferroptosis-Related Gene Signature to Predict Prognosis in Patients with Head and Neck Squamous Cell Carcinoma.

Dis Markers. 2021

[2]
Development and validation of a novel ferroptosis-related gene signature for predicting prognosis and immune microenvironment in head and neck squamous cell carcinoma.

Int Immunopharmacol. 2021-9

[3]
Development and validation of a fourteen- innate immunity-related gene pairs signature for predicting prognosis head and neck squamous cell carcinoma.

BMC Cancer. 2020-10-20

[4]
Identification and validation of an individualized prognostic signature of lung squamous cell carcinoma based on ferroptosis-related genes.

Thorac Cancer. 2021-12

[5]
Identification of AURKA as a Biomarker Associated with Cuproptosis and Ferroptosis in HNSCC.

Int J Mol Sci. 2024-4-16

[6]
Autophagy-Related Signature for Head and Neck Squamous Cell Carcinoma.

Dis Markers. 2020

[7]
Ferroptosis-associated DNA methylation signature predicts overall survival in patients with head and neck squamous cell carcinoma.

BMC Genomics. 2022-1-18

[8]
Identification of a Ferroptosis Gene Set That Mediates the Prognosis of Squamous Cell Carcinoma of the Head and Neck.

Front Genet. 2021-9-3

[9]
Six Glycolysis-Related Genes as Prognostic Risk Markers Can Predict the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma.

Biomed Res Int. 2021

[10]
Ferroptosis-related gene signature predicts the prognosis in Oral squamous cell carcinoma patients.

BMC Cancer. 2021-7-20

引用本文的文献

[1]
CD46 TREM1 regulates the autophagy marker LC3B ATG5 in oral squamous cell carcinoma.

Front Oncol. 2025-5-22

[2]
Detection of Circulating mRNA Variants in Hepatocellular Carcinoma Patients Using Targeted RNAseq.

Liver Cancer. 2025-4-4

[3]
Peroxiredoxin 6 in Stress Orchestration and Disease Interplay.

Antioxidants (Basel). 2025-3-23

[4]
Ferroptosis-Related Gene Signatures: Prognostic Role in HPV-Positive Oropharyngeal Squamous Cell Carcinoma.

Cancers (Basel). 2025-2-5

[5]
SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1.

Oncol Rep. 2024-2

[6]
The Role of Deubiquitinating Enzyme in Head and Neck Squamous Cell Carcinoma.

Int J Mol Sci. 2022-12-29

本文引用的文献

[1]
An immune-related seven-lncRNA signature for head and neck squamous cell carcinoma.

Cancer Med. 2021-4

[2]
Identification of Three Autophagy-Related Long Non-Coding RNAs as a Novel Head and Neck Squamous Cell Carcinoma Prognostic Signature.

Front Oncol. 2021-1-26

[3]
A Novel Ferroptosis-Associated Gene Signature to Predict Prognosis in Patients with Uveal Melanoma.

Diagnostics (Basel). 2021-2-2

[4]
Recent Advances and Future Directions in Clinical Management of Head and Neck Squamous Cell Carcinoma.

Cancers (Basel). 2021-1-18

[5]
Prognostic Correlation of an Autophagy-Related Gene Signature in Patients with Head and Neck Squamous Cell Carcinoma.

Comput Math Methods Med. 2020

[6]
Low expression of ferritinophagy-related NCOA4 gene in relation to unfavorable outcome and defective immune cells infiltration in clear cell renal carcinoma.

BMC Cancer. 2021-1-5

[7]
3-MA Enhanced Chemosensitivity in Cisplatin Resistant Hypopharyngeal Squamous Carcinoma Cells via Inhibiting Beclin -1 Mediated Autophagy.

Curr Pharm Des. 2021

[8]
Clinical and Biological Significances of a Ferroptosis-Related Gene Signature in Glioma.

Front Oncol. 2020-11-20

[9]
Head and neck squamous cell carcinoma.

Nat Rev Dis Primers. 2020-11-26

[10]
SLC7A11 as a biomarker and therapeutic target in HPV-positive head and neck Squamous Cell Carcinoma.

Biochem Biophys Res Commun. 2020-12-17

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索