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GPI 锚：按需调控。

GPI anchors: Regulated as needed.

机构信息

Department of Cell Biology, Faculty of Biology, University of Seville, Seville, Spain.

Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla , Seville, Spain.

出版信息

J Cell Biol. 2023 May 1;222(5). doi: 10.1083/jcb.202303097. Epub 2023 Apr 13.

DOI:10.1083/jcb.202303097
PMID:37052883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10114539/
Abstract

GPI anchoring is an essential post-translational modification in eukaryotes that links proteins to the plasma membrane. In this issue, Liu et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202208159) suggest, for the first time, a regulation on demand of the GPI glycolipid precursor biosynthesis.

摘要

糖基磷脂酰肌醇（GPI）锚定是真核生物中一种重要的翻译后修饰过程，它将蛋白质与质膜连接在一起。在本期中，Liu 等人（2023. J. Cell Biol. https://doi.org/10.1083/jcb.202208159）首次提出了一种对 GPI 糖脂前体生物合成的按需调节机制。

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GPI anchors: Regulated as needed.GPI 锚：按需调控。
J Cell Biol. 2023 May 1;222(5). doi: 10.1083/jcb.202303097. Epub 2023 Apr 13.
2
Glycosylphosphatidylinositol membrane anchors in Saccharomyces cerevisiae: absence of ceramides from complete precursor glycolipids.酿酒酵母中的糖基磷脂酰肌醇膜锚定物：完整前体糖脂中不存在神经酰胺。
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Structural remodeling of GPI anchors during biosynthesis and after attachment to proteins.在生物合成过程中和与蛋白质结合后，GPI 锚的结构重塑。
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Identification of complete precursors for the glycosylphosphatidylinositol protein anchors of Trypanosoma cruzi.克氏锥虫糖基磷脂酰肌醇蛋白锚定物完整前体的鉴定
J Biol Chem. 1996 Jul 12;271(28):16877-87. doi: 10.1074/jbc.271.28.16877.
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Thematic review series: lipid posttranslational modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipids.专题综述系列：脂质翻译后修饰。酵母和哺乳动物细胞中蛋白质的糖基磷脂酰肌醇锚定，或者说：我们如何学会不再担忧并爱上糖脂。
J Lipid Res. 2007 May;48(5):993-1011. doi: 10.1194/jlr.R700002-JLR200. Epub 2007 Mar 14.
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Recent progress in synthetic and biological studies of GPI anchors and GPI-anchored proteins.糖基磷脂酰肌醇（GPI）锚和 GPI-锚定蛋白的合成和生物学研究的最新进展。
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YLL031c belongs to a novel family of membrane proteins involved in the transfer of ethanolaminephosphate onto the core structure of glycosylphosphatidylinositol anchors in yeast.YLL031c属于一个新型膜蛋白家族，该家族参与将磷酸乙醇胺转移到酵母中糖基磷脂酰肌醇锚的核心结构上。
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Metabolic Labeling and Structural Analysis of Glycosylphosphatidylinositols from Parasitic Protozoa.寄生原生动物糖基磷脂酰肌醇的代谢标记与结构分析
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Glycosyl-phosphatidylinositol molecules of the parasite and the host.寄生虫和宿主的糖基磷脂酰肌醇分子。
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Biosynthesis of the side chain of yeast glycosylphosphatidylinositol anchors is operated by novel mannosyltransferases located in the endoplasmic reticulum and the Golgi apparatus.酵母糖基磷脂酰肌醇锚定物侧链的生物合成由位于内质网和高尔基体中的新型甘露糖基转移酶负责。
J Biol Chem. 1995 Aug 25;270(34):19709-15. doi: 10.1074/jbc.270.34.19709.

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本文引用的文献

1
Biosynthesis and biology of mammalian GPI-anchored proteins.哺乳动物 GPI-锚定蛋白的生物合成与生物学。
Open Biol. 2020 Mar;10(3):190290. doi: 10.1098/rsob.190290. Epub 2020 Mar 11.
2
Biosynthesis and deficiencies of glycosylphosphatidylinositol.糖基磷脂酰肌醇的生物合成与缺陷。
Proc Jpn Acad Ser B Phys Biol Sci. 2014;90(4):130-43. doi: 10.2183/pjab.90.130.
3
Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulum.酵母ARV1在糖基磷脂酰肌醇（GPI）组装过程中，对于将早期GPI中间体有效传递给首个甘露糖基转移酶是必需的，并且控制着来自内质网的脂质流动。
Mol Biol Cell. 2008 May;19(5):2069-82. doi: 10.1091/mbc.e07-08-0740. Epub 2008 Feb 20.
4
Post-translational GPI lipid anchor modification of proteins in kingdoms of life: analysis of protein sequence data from complete genomes.生命王国中蛋白质的翻译后糖基磷脂酰肌醇脂质锚定修饰：来自完整基因组的蛋白质序列数据分析
Protein Eng. 2001 Jan;14(1):17-25. doi: 10.1093/protein/14.1.17.