序贯双额叶低频重复经颅磁刺激治疗原发性失眠的开放标签先导试验。
An open label pilot trial of sequential bifrontal low frequency r-TMS in the treatment of primary insomnia.
机构信息
Department of Psychiatry, University of Florida College of Medicine, 4037 NW 86 Terrace, Gainesville, FL 32606, USA.
Department of Psychiatry, University of Florida, College of Medicine, 4037 NW 86th Terrace, Gainesville, FL, USA.
出版信息
Psychiatry Res. 2023 Jun;324:115194. doi: 10.1016/j.psychres.2023.115194. Epub 2023 Apr 9.
Abstract
This pilot study examines the therapeutic effects of bifrontal low frequency (LF) TMS on primary insomnia. In this prospective, open-label study 20 patients with primary insomnia and without major depressive disorder received 15 sequential bifrontal LF rTMS stimulation sessions. By week 3, PSQI scores declined from baseline score of 12.57(sd 2.74) to 9.50 (sd 4.27), a large effects size (0.80 (CI 0.29, 1.36)), and CGI-I scores improved for 52.6% of participants. Results of this pilot indicate that the novel bifrontal LF rTMS benefitted this group of patients suffering from primary insomnia, with absence of sham control a significant study limitation.
摘要
本研究旨在探讨双额叶低频（LF）重复经颅磁刺激（rTMS）治疗原发性失眠的疗效。在这项前瞻性、开放标签研究中，20 例原发性失眠且无重性抑郁障碍的患者接受了 15 次双额叶 LF rTMS 连续刺激。到第 3 周时，匹兹堡睡眠质量指数（PSQI）评分从基线的 12.57（sd 2.74）下降至 9.50（sd 4.27），具有较大的效应量（0.80（CI 0.29，1.36）），52.6%的参与者的临床总体印象-改善量表（CGI-I）评分得到改善。这项研究结果表明，新型双额叶 LF rTMS 对原发性失眠患者有益，由于缺乏假刺激对照，这是一个显著的研究局限性。
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