Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, Guiyang, China; Guizhou Engineering Laboratory for Quality Control ＆Evaluation Technology of Medicine, Guizhou Normal University, Guiyang, China.
The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guizhou, Guiyang, China.
J Ethnopharmacol. 2023 Aug 10;312:116490. doi: 10.1016/j.jep.2023.116490. Epub 2023 Apr 11.
Opuntia speciesis used in traditional medicine to treat diabetes mellitus (DM). Polysaccharide is one of the main components of Opuntia. Opuntia polysaccharide (OPS) is a kind of natural active macromolecular substance, numerous animal experiments have been conducted to treat DM, however, its protective effect and mechanism in animal models of DM has not been clarified.
The aim of this study is to evaluate the efficacy of OPS on DM through a stematic review and meta-analysis of animal models, and whether its improves blood glucose (BG) levels, body weight (BW), food intake, water intake, and lipid levels, and to summarize the potential mechanism of OPS in the treatment of DM.
We searched relevant Chinese and English databases from the date of construction to March 2022, including PubMed (MEDLINE), Embase, Cochrane Library, Scopus and Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Biomedicine Literature Database (CBM), Chinese Science and Technology Periodicals Database (VIP), Wanfang Database. 16 studies were included for meta-analysis.
The results showed that compared with the model group, the OPS significantly improved BG, BW, food intake, water intake, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). Meta-regression and subgroup analysis showed that intervention dose, animal species, duration and modeling method may be the source of the heterogeneity. There was no statistical difference between the positive control group and the OPS treatment group in improving BW, food intake, water intake, TC, TG, HDL-C, and LDL-C.
OPS can effectively improve the symptoms of hyperglycemia, polydipsia, polyphagia, low body weight, and dyslipidemia in DM animals. The possible protective mechanisms of OPS on DM animals are immune regulation, repair of damaged pancreatic β cells, and inhibition of oxidative stress and cell apoptosis.
仙人掌属植物被用于传统医学治疗糖尿病（DM）。多糖是仙人掌属植物的主要成分之一。仙人掌多糖（OPS）是一种天然的活性高分子物质，已有大量动物实验用于治疗 DM，但它在 DM 动物模型中的保护作用及其机制尚未阐明。
本研究旨在通过对动物模型的系统评价和荟萃分析，评估 OPS 对 DM 的疗效，以及其是否能改善血糖（BG）水平、体重（BW）、摄食量、饮水量和血脂水平，并总结 OPS 治疗 DM 的潜在机制。
我们检索了相关的中、英文数据库，包括 PubMed（MEDLINE）、Embase、Cochrane 图书馆、Scopus 和 Web of Science、中国知网（CNKI）、中国生物医学文献数据库（CBM）、中国科技期刊数据库（VIP）、万方数据库，从建库日期到 2022 年 3 月，共纳入 16 项研究进行荟萃分析。
结果表明，与模型组相比，OPS 能显著改善 BG、BW、摄食量、饮水量、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）。Meta 回归和亚组分析显示，干预剂量、动物种类、持续时间和建模方法可能是异质性的来源。在改善 BW、摄食量、饮水量、TC、TG、HDL-C 和 LDL-C 方面，阳性对照组与 OPS 治疗组之间无统计学差异。
OPS 能有效改善 DM 动物的高血糖、多饮、多食、体重减轻和血脂异常症状。OPS 对 DM 动物的可能保护机制是免疫调节、受损胰腺β细胞的修复、以及抑制氧化应激和细胞凋亡。
