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腹主动脉瘤的血流、生物传热及心脏热脉冲研究。

Study of flow, Bioheat transfer and cardiac thermal pulse of aneurysm in the abdominal aortic.

作者信息

Ng Eddie Y K, Looi Leonard Jun Cong

机构信息

School of Mechanical and Aerospace Engineering, College of Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.

School of Mechanical and Aerospace Engineering, College of Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.

出版信息

J Therm Biol. 2023 Apr;113:103481. doi: 10.1016/j.jtherbio.2023.103481. Epub 2023 Feb 16.

Abstract

Abdominal aortic aneurysms (AAA) are serious and difficult to detect conditions that can be deadly if they rupture. Infrared thermography (IRT) is a promising imaging technique that can detect abdominal aortic aneurysms more quickly and less costly than other imaging techniques. A clinical biomarker of circular thermal elevation on the midriff skin surface of AAA patient at various scenarios was expected during diagnosis using IRT scanner. However, it is important to note that thermography is not a perfect technology, and it does have some limitations, such as lack of clinical trials. There is still work to be done to improve this imaging technique and make it a more viable and accurate method in detecting abdominal aortic aneurysms. Nevertheless, thermography is currently one of the most convenient technologies in imaging, and it has the potential to detect abdominal aortic aneurysms earlier than other techniques. Cardiac thermal pulse (CTP), on the other hand, was used to examine the thermal physics of AAA. AAA had a CTP that only responded to systolic phase at regular body temperature. Whereas the AAA wall would establish thermal homeostasis with blood temperature following a quasi-linear relationship as the body experienced fever or stage-2 hypothermia. In contrast, a healthy abdominal aorta displayed a CTP that responded to the full cardiac cycle, including diastolic phase at all simulated scenarios.

摘要

腹主动脉瘤(AAA)是严重且难以检测的病症,如果破裂可能会致命。红外热成像(IRT)是一种很有前景的成像技术,与其他成像技术相比,它能更快且成本更低地检测出腹主动脉瘤。在使用IRT扫描仪进行诊断时,人们期望能找到AAA患者在各种情况下腹部皮肤表面环形热升高的临床生物标志物。然而,需要注意的是,热成像并非完美技术,它确实存在一些局限性,比如缺乏临床试验。要改进这种成像技术并使其在检测腹主动脉瘤方面成为更可行、更准确的方法,仍有工作要做。尽管如此,热成像目前是成像领域最便捷的技术之一,并且它有潜力比其他技术更早地检测出腹主动脉瘤。另一方面,心脏热脉冲(CTP)被用于研究AAA的热物理学。AAA的CTP在正常体温下仅对收缩期有反应。而当身体发热或处于二期低温时,AAA壁会与血液温度建立近似线性关系的热稳态。相比之下,健康的腹主动脉在所有模拟情况下的CTP对整个心动周期都有反应,包括舒张期。

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