Sim Jae Eun, Song Ha-Na, Choi Jong-Un, Lee Ji-Eun, Baek In Young, Cho Hwan-Ho, Kim Jong-Hoon, Chung Jong-Won, Kim Gyeong-Moon, Park Hyun-Jin, Bang Oh Young, Seo Woo-Keun
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Department of Electronic Electrical and Computer Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Front Neurol. 2023 Mar 28;14:1069502. doi: 10.3389/fneur.2023.1069502. eCollection 2023.
Pleiotropic effects of statins result in the stabilization of symptomatic intracranial arterial plaque. However, little is known about the effect of statins in non-symptomatic cerebral arteries. We hypothesized that intensive statin therapy could produce a change in the non-symptomatic cerebral arteries.
This is a sub-study of a prospective observational study under the title of "Intensive Statin Treatment in Acute Ischemic Stroke Patients with Intracranial Atherosclerosis: a High-Resolution Magnetic Resonance Imaging (HR-MRI) study." Patients with statin-naive acute ischemic stroke who had symptomatic intracranial artery stenosis (above 50%) were recruited for this study. HR-MRI was performed to assess the patients' cerebral arterial status before and 6 months after the statin therapy. To demonstrate the effect of statins in the non-symptomatic segment of intracranial cerebral arteries, we excluded symptomatic segments from the data to be analyzed. We compared the morphological changes using cerebrovascular morphometry.
A total of 54 patients (mean age: 62.9 ± 14.4 years, 59.3% women) were included in this study. Intensive statin therapy produced significant morphological changes of overall cerebral arteries. Among the morphological features, the arterial luminal area showed the highest number of significant changes with a range from 5.7 and 6.7%. Systolic blood pressure (SBP) was an independent factor associated with relative changes in posterior circulation bed maximal diameter percentage change (beta -0.21, 95% confidence interval -0.36 to -0.07, = 0.005).
Intensive statin therapy produced a favorable morphological change in cerebral arteries of not only the target arterial segment but also non-symptomatic arterial segments. The change in cerebral arterial luminal diameter was influenced by the baseline SBP and was dependent on the topographic distribution of the cerebral arteries.: ClinicalTrials.gov, identifier NCT02458755.
他汀类药物具有多效性，可使有症状的颅内动脉斑块稳定。然而，关于他汀类药物对无症状脑动脉的影响知之甚少。我们推测强化他汀治疗可能会使无症状脑动脉产生变化。
这是一项前瞻性观察性研究的子研究，题目为“颅内动脉粥样硬化急性缺血性卒中患者的强化他汀治疗：一项高分辨率磁共振成像（HR-MRI）研究”。本研究招募了有症状性颅内动脉狭窄（超过50%）且未使用过他汀类药物的急性缺血性卒中患者。在他汀治疗前和治疗6个月后进行HR-MRI，以评估患者的脑动脉状况。为了证明他汀类药物对颅内脑动脉无症状节段的影响，我们在分析数据时排除了有症状节段。我们使用脑血管形态测量法比较形态学变化。
本研究共纳入54例患者（平均年龄：62.9±14.4岁，59.3%为女性）。强化他汀治疗使脑动脉总体形态发生了显著变化。在形态学特征中，动脉管腔面积的显著变化数量最多，范围为5.7%至6.7%。收缩压（SBP）是与后循环床最大直径百分比变化的相对变化相关的独立因素（β -0.21，95%置信区间 -0.36至 -0.07，P = 0.005）。
强化他汀治疗不仅使目标动脉节段，也使无症状动脉节段的脑动脉产生了有利的形态学变化。脑动脉管腔直径的变化受基线SBP影响，并取决于脑动脉的地形分布。：ClinicalTrials.gov标识符NCT02458755
