State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 361102, China.
Theranostics. 2023 Mar 5;13(5):1545-1570. doi: 10.7150/thno.82790. eCollection 2023.
Pathogenic bacterial infections represent an ever-growing crisis, now significantly threatening life expectancy across the worldwide population and thus novel approaches to tackle this issue are urgently needed. The application of nanotechnology in recent years has opened up new horizons in the selective or specific delivery of drugs or imaging agents to infectious sites. In particular, the development of nanoparticles for both delivery of active substances and imaging of infection sites is now gathering much interest. Although still in its infancy, the field of antibacterial nanomedicines provides exciting new possibilities to combat multi-resistant bacterial infections and shows great promise for personalized medicine in antibacterial stewardship. This review examines nanoparticle-based formulations used for therapeutic delivery, pathogen tracking in diagnosis, and combined "theranostic" approaches to more effectively treating bacterial infections.
致病细菌感染是一个日益严重的危机，现在严重威胁着全球人口的预期寿命，因此迫切需要新的方法来解决这个问题。近年来，纳米技术的应用为有针对性地输送药物或成像剂开辟了新的途径。特别是，用于输送活性物质和感染部位成像的纳米颗粒的开发现在引起了广泛关注。尽管还处于起步阶段，但抗菌纳米医学领域为对抗多耐药性细菌感染提供了令人兴奋的新可能性，并为抗菌管理的个性化医学带来了巨大的希望。本文综述了用于治疗性药物输送、病原体诊断追踪以及联合“治疗诊断”方法的基于纳米颗粒的制剂，以更有效地治疗细菌感染。
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