Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha, China.
Xiangya School of Medicine, Central South University, Changsha, China.
Front Cell Infect Microbiol. 2023 Mar 28;13:1103626. doi: 10.3389/fcimb.2023.1103626. eCollection 2023.
Mucormycosis is considered the fourth most common invasive fungal disease after candidiasis, aspergillosis and cryptococcosis. species accounted for 5%-29% of all mucormycosis. However, available data on species-specific analysis of infections are limited.
This study included nine patients hospitalized in five hospitals in two cities in south China with mucormycosis or colonization caused by Lichtheimia species, diagnosed mainly by metagenomic next-generation sequencing (mNGS). The corresponding medical records were reviewed, and the clinical data analyzed included demographic characteristics, site of infection, host factors and type of underlying disease, diagnosis, clinical course, management, and prognosis.
In this study, nine patients with infections or colonization had a recent history of haematological malignancy (33.3%), solid organ transplants (33.3%), pulmonary disease (22.2%), and trauma (11.1%) and were categorized as 11.1% (one case) proven, 66.7% (six cases) probable mucormycosis and 22.2% (two cases) colonization. Pulmonary mucormycosis or colonization was the predominant presentation in 77.8% of cases and mucormycosis caused by resulted in death in four out of seven patients (57.1%).
These cases highlight the importance of early diagnosis and combined therapy for these sporadic yet life-threatening infections. Further studies on the diagnosis and control of infection in China are required.
毛霉病被认为是继念珠菌病、曲霉病和隐球菌病之后第四种最常见的侵袭性真菌感染。希木龙属占所有毛霉病的 5%-29%。然而，关于希木龙属感染的种特异性分析的数据有限。
本研究纳入了 9 例在中国南方两个城市的 5 家医院因希木龙属而住院的毛霉病或定植患者，主要通过宏基因组二代测序（mNGS）诊断。回顾了相应的病历记录，并分析了包括人口统计学特征、感染部位、宿主因素和基础疾病类型、诊断、临床病程、治疗和预后在内的临床数据。
在本研究中，9 例希木龙属感染或定植患者均有近期血液系统恶性肿瘤（33.3%）、实体器官移植（33.3%）、肺部疾病（22.2%）和创伤（11.1%）病史，确诊为 11.1%（1 例）、拟诊为 66.7%（6 例）的毛霉病和 22.2%（2 例）定植。77.8%的病例以肺部毛霉病或定植为主要表现，7 例中有 4 例（57.1%）因希木龙属引起的毛霉病死亡。
这些病例强调了早期诊断和联合治疗这些偶发性但危及生命的感染的重要性。需要在中国开展关于希木龙属感染的诊断和控制的进一步研究。
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