He Guo-Qian, Xiao Ling, Pan Zhen, Wu Jian-Rong, Liang Dong-Ni, Guo Xia, Jiang Ming-Yan, Gao Ju
Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Front Oncol. 2022 Aug 15;12:949910. doi: 10.3389/fonc.2022.949910. eCollection 2022.
Mucormycosis caused by is an emerging and uncommon opportunistic infection in patients with hematological malignancies, with high mortality rates. Herein, we first report a case of pulmonary mucormycosis with in a 3-year-old girl recently diagnosed with B-cell acute lymphoblastic leukemia. The diagnosis was made using computerized tomography of the lung, metagenomic next-generation sequencing (mNGS) of blood and sputum specimens, and microscopic examination to detect the development of on the surgical specimen. She was effectively treated after receiving prompt treatment with amphotericin B and posaconazole, followed by aggressive surgical debridement. In our case, the fungal isolates were identified as using mNGS, which assisted clinicians in quickly and accurately diagnosing and initiating early intensive treatment. This case also indicated the importance of strong clinical suspicion, as well as aggressive antifungal therapy combined with surgical debridement of affected tissues.
由 引起的毛霉病是血液系统恶性肿瘤患者中一种新出现的罕见机会性感染，死亡率很高。在此，我们首次报告一例3岁女童的肺部毛霉病病例，该女童最近被诊断为B细胞急性淋巴细胞白血病。通过肺部计算机断层扫描、血液和痰液标本的宏基因组下一代测序（mNGS）以及显微镜检查来检测手术标本上 的生长情况，从而做出诊断。她在接受两性霉素B和泊沙康唑的及时治疗，随后进行积极的手术清创后得到了有效治疗。在我们的病例中，使用mNGS将真菌分离株鉴定为 ，这有助于临床医生快速准确地诊断并启动早期强化治疗。该病例还表明了强烈临床怀疑的重要性，以及积极的抗真菌治疗与受影响组织的手术清创相结合的重要性。
