Klepzig H, Reifart N, Baum R, Skupin M, Standke R, Satter P, Hör G, Kaltenbach M
Z Kardiol. 1986 Mar;75(3):170-5.
After aortic valve replacement for chronic aortic regurgitation, complete normalization of the left ventricular end-diastolic volume can rarely be observed. We therefore investigated the role of continual volume overload caused by persisting concomitant mitral regurgitation. 20 patients who received an aortic valve for chronic aortic regurgitation (group 1), 5 patients after operation for aortic stenosis (group 2) and 6 patients with double valve replacement because of aortic and mitral valve lesions were included in the study 1 to 108 months after operation. All patients were examined clinically and by combined first pass/equilibrium radionuclide ventriculography. In the case of significant regurgitation (greater than 20%) 2-dimensional colour-coded Doppler-echocardiography was performed in patients of group 1 to localize the regurgitant lesion. 15 patients of group 1 had a typical systolic murmur indicating mitral regurgitation. 14 of these patients had significant scintigraphic left-sided heart regurgitation: 7 patients had regurgitant fractions between 21 and 40%; 6 patients between 41 and 60%; in 1 patient RF was 64%. Echocardiography confirmed mitral regurgitation in 9 of 11 of these cases. No significant regurgitation was observed in patients of group 2; mild regurgitation was measured in 5 of 6 patients of group 3 (26 to 31%). We conclude that in patients with chronic aortic regurgitation complete normalization of the left ventricular end-diastolic volume after valve replacement may not occur in some patients because of persisting mitral regurgitation.
在因慢性主动脉瓣反流进行主动脉瓣置换术后,很少能观察到左心室舒张末期容积完全恢复正常。因此,我们研究了持续存在的二尖瓣反流所导致的持续容量超负荷的作用。本研究纳入了20例因慢性主动脉瓣反流接受主动脉瓣置换术的患者(第1组)、5例接受主动脉瓣狭窄手术的患者(第2组)以及6例因主动脉瓣和二尖瓣病变接受双瓣膜置换术的患者,观察时间为术后1至108个月。所有患者均接受了临床检查以及首次通过/平衡放射性核素心室造影检查。对于存在显著反流(大于20%)的情况,对第1组患者进行了二维彩色编码多普勒超声心动图检查,以定位反流病变。第1组中有15例患者有典型的收缩期杂音,提示二尖瓣反流。其中14例患者有明显的放射性核素左侧心脏反流:7例患者的反流分数在21%至40%之间;6例患者在41%至60%之间;1例患者的反流分数为64%。超声心动图证实其中11例中的9例存在二尖瓣反流。第2组患者未观察到明显反流;第3组6例患者中有5例测量到轻度反流(26%至31%))。我们得出结论,对于慢性主动脉瓣反流患者,由于持续存在二尖瓣反流,部分患者在瓣膜置换术后左心室舒张末期容积可能无法完全恢复正常。