Jin Weitao, Ye Xun, Chen Xiaolin, Duan Ran, Zhao Yang, Zhang Yukun, Wang Weijing, Lou Xin, Zhao Yuanli, Ma Ning, Wang Rong
Department of Neurosurgery, Peking University International Hospital, Peking University, Beijing, China.
Department of Neurosurgery, Capital Medical University affiliated Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.
Biotechnol Genet Eng Rev. 2023 Apr 14;40(3):2760-2775. doi: 10.1080/02648725.2023.2202522.
Recanalization of chronic occluded internal carotid arteries has the potential to provide significant benefits for patients in the future, but the procedure is technically challenging. Therefore, this study aimed to identify a better method to predict the success of recanalization for patients with chronic internal carotid artery occlusion. The study's overall success rate was 73.77%. The multivariate logistic regression analysis revealed that two factors were independent predictors of successful recanalization: the continuous low signal lumen in the occluded segment of the internal carotid artery on the MRI image without contrast (OR: 15.9; 95% CI: 2.67-94.63) and the architecture of the clinoid segment of the internal carotid artery on the MRI image with contrast (OR: 11.97; 95% CI: 2.44-58.79). Based on the model coefficient, the researchers established an MRI score system. The MRI score system's area under the curve (AUC) in predicting successful recanalization was 0.916 (95% CI: 0.815 to 0.972; < 0.001) with a sensitivity of 83.33% and a specificity of 72.22%. Compared to the previous score system based on the DSA morphology, the MRI system had a similar sensitivity and a better specificity. Therefore, the continuous low signal lumen in the occluded segment of the internal carotid artery on the MRI image without contrast and the architecture of the clinoid segment of the internal carotid artery on the MRI image with contrast were identified as independent predictors for successful recanalization in patients with chronic internal carotid artery occlusion (CICAO).
慢性闭塞性颈内动脉再通术未来有可能为患者带来显著益处,但该手术在技术上具有挑战性。因此,本研究旨在确定一种更好的方法来预测慢性颈内动脉闭塞患者再通术的成功率。该研究的总体成功率为73.77%。多因素逻辑回归分析显示,两个因素是再通成功的独立预测因素:MRI图像上无造影剂时颈内动脉闭塞段的持续低信号管腔(OR:15.9;95%CI:2.67 - 94.63)以及MRI图像上有造影剂时颈内动脉床突段的结构(OR:11.97;95%CI:2.44 - 58.79)。基于模型系数,研究人员建立了一个MRI评分系统。该MRI评分系统预测再通成功的曲线下面积(AUC)为0.916(95%CI:0.815至0.972;P<0.001),敏感性为83.33%,特异性为72.22%。与先前基于DSA形态学的评分系统相比,MRI系统具有相似的敏感性和更好的特异性。因此,MRI图像上无造影剂时颈内动脉闭塞段的持续低信号管腔以及MRI图像上有造影剂时颈内动脉床突段的结构被确定为慢性颈内动脉闭塞(CICAO)患者再通成功的独立预测因素。