Division of Pediatric Surgery, Department of Surgery, Duke University Medical Center, Durham, NC, USA.
Department of Pediatric Surgery, Centro Hospitalar Universitário São João, Porto, Portugal.
Pediatr Blood Cancer. 2023 May;70 Suppl 2:e30338. doi: 10.1002/pbc.30338. Epub 2023 Apr 14.
Although general treatment approaches for Wilms tumor differ between Children's Oncology Group and Société Internationale d'Oncologie Pédiatrique-Renal Tumors Study Group protocols, complex tumors that may be candidates for nephron sparing surgery (NSS) and those with intravascular tumor extension represent a management challenge. In both of these scenarios, anatomic considerations are important in guiding management, making these areas of significant similarities in management between the international groups. This paper aims to explore the current approaches to NSS and intravascular tumor extension by both international groups, with attention to the evidence supporting these approaches and current knowledge gaps.
尽管儿童肿瘤协作组（Children's Oncology Group）和国际小儿肿瘤学会肾脏肿瘤研究组（Société Internationale d'Oncologie Pédiatrique-Renal Tumors Study Group）的 Wilms 肿瘤治疗方案存在差异，但对于可能适合保留肾单位手术（nephron sparing surgery，NSS）的复杂肿瘤和伴有血管内肿瘤延伸的肿瘤，其治疗仍然是一个挑战。在这两种情况下，解剖学考虑因素对于指导治疗非常重要，这使得国际治疗组在这些领域的管理具有显著的相似性。本文旨在探讨国际治疗组在保留肾单位手术和血管内肿瘤延伸方面的当前方法，重点关注支持这些方法的证据和当前的知识空白。
