[神经外科患者的色氨酸负荷及其血浆浓度]

[Tryptophan loading and its plasma concentration in neurosurgical patients].

作者信息

Levchenko L I, Promyslov M Sh, Rakier A Ia

出版信息

Zh Vopr Neirokhir Im N N Burdenko. 1986 Mar-Apr(2):31-3.

Abstract

Tests for blood plasma tryptophan in patients with various diseases of the nervous system showed a statistically significant increase of its content in tumors of the astrocytic series in patients with meningiomas and oligodendrogliomas. The character of the tryptophan excretion curve after a load in neurooncological patients was different from that in healthy individuals and patients with thrombosis of the sinus and arachnoencephalitis. Hydrocortisone injection normalized the tryptophan curve in patients and, consequently, also the tryptophanpyrrolase reaction which is evidently disturbed in neurooncological patients.

摘要

对患有各种神经系统疾病的患者进行的血浆色氨酸检测显示，在患有脑膜瘤和少突胶质细胞瘤的患者中，星形细胞系列肿瘤中色氨酸含量在统计学上有显著增加。神经肿瘤患者在负荷后色氨酸排泄曲线的特征与健康个体以及患有窦血栓形成和蛛网膜炎的患者不同。注射氢化可的松可使患者的色氨酸曲线恢复正常，因此也可使神经肿瘤患者中明显受到干扰的色氨酸吡咯酶反应恢复正常。