心脏磁共振成像上的左右心室血池T2比值与肺动脉高压患者的血流动力学相关。

Right and left ventricular blood pool T2 ratio on cardiac magnetic resonance imaging correlates with hemodynamics in patients with pulmonary hypertension.

作者信息

Deng Mei, Liu Anqi, Xu Wenqing, Yang Haoyu, Gao Qian, Zhang Ling, Zhen Yanan, Liu Xiaopeng, Xie Wanmu, Liu Min

机构信息

Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China.

Department of Radiology, Peking University China-Japan Friendship School of Clinical Medicine, Beijing, 100191, China.

出版信息

Insights Imaging. 2023 Apr 15;14(1):66. doi: 10.1186/s13244-023-01406-9.

DOI:10.1186/s13244-023-01406-9

PMID:37060418

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10105812/

Abstract

OBJECTIVES

Our objective is to compare the right/left ventricular blood pool T1 ratio (RVT1/LVT1), and right/left ventricular blood pool T2 ratio (RVT2/LVT2) on Cardiac Magnetic Resonance Imaging (CMR) between patients with pulmonary hypertension (PH) and normal controls, to analyze the correlation of RVT1/LVT1, RVT2/LVT2 and hemodynamics measured with right heart catheterization (RHC) in patients with PH.

METHODS

Forty two patients with PH and 40 gender-and age-matched healthy controls were prospectively included. All patients underwent RHC and CMR within 24 h. The right and left ventricular blood pool T1 and T2 values were respectively measured, and RVT1/LVT1 and RVT2/LVT2 between the PH group and the healthy control were compared. Meanwhile, the correlation between RVT1/LVT1, RV/LVT2 ratio and hemodynamic parameters in patients with PH respectively was analyzed.

RESULTS

In the control group, RVT2 was significantly lower than LVT2 (t = 6.782, p < 0.001) while RVT1 also was lower than LVT1 (t = 8.961, p < 0.001). In patients with PH, RVT2 was significantly lower than LVT2 (t = 9.802, p < 0.001) while RVT1 was similar to LVT1 (t = - 1.378, p = 0.176). RVT2/LVT2 in the PH group was significantly lower than that in the control group (p < 0.001). RVT1/LVT1 in PH patients increased in comparison with the control group (p < 0.001). RVT2/LVT2 negatively correlated with pulmonary vascular resistance (r = - 0.506) and positively correlated with cardiac index (r = 0.521), blood oxygen saturation in Superior vena cava, right atrium, right ventricle and pulmonary artery (r = 0.564, 0.603, 0.648, 0.582).

CONCLUSIONS

RVT2/LVT2 on T2 mapping could be an additional CMR imaging marker that may assist to evaluate the severity of PH.

摘要

目的

我们的目的是比较肺动脉高压（PH）患者与正常对照者在心脏磁共振成像（CMR）上的右/左心室血池T1比值（RVT1/LVT1）和右/左心室血池T2比值（RVT2/LVT2），分析PH患者中RVT1/LVT1、RVT2/LVT2与右心导管检查（RHC）测量的血流动力学之间的相关性。

方法

前瞻性纳入42例PH患者和40例年龄及性别匹配的健康对照者。所有患者在24小时内接受了RHC和CMR检查。分别测量右心室和左心室血池的T1和T2值，比较PH组与健康对照组之间的RVT1/LVT1和RVT2/LVT2。同时，分别分析PH患者中RVT1/LVT1、RVT2/LVT2与血流动力学参数之间的相关性。

结果

在对照组中，RVT2显著低于LVT2（t = 6.782，p < 0.001），而RVT1也低于LVT1（t = 8.961，p < 0.001）。在PH患者中，RVT2显著低于LVT2（t = 9.802，p < 0.001），而RVT1与LVT1相似（t = -1.378，p = 0.176）。PH组的RVT2/LVT2显著低于对照组（p < 0.001）。与对照组相比，PH患者的RVT1/LVT1升高（p < 0.001）。RVT2/LVT2与肺血管阻力呈负相关（r = -0.506），与心脏指数呈正相关（r = 0.521），与上腔静脉、右心房、右心室和肺动脉的血氧饱和度呈正相关（r = 0.564、0.603、0.648、0.582）。