Institute for Zoology, Leopold-Franzens-Universität Innsbruck, Technikerstr. 25, 6020, Innsbruck, Austria.
Center for Molecular Biosciences, Universität Innsbruck, Innsbruck, Austria.
J Comp Physiol B. 2023 Jun;193(3):307-313. doi: 10.1007/s00360-023-01486-5. Epub 2023 Apr 15.
In a recent study, a large number of transport proteins was detected in the transcriptome and proteome of saline perfused rete mirabile tissue of the European eel. In this study, the data set was reanalyzed for the presence of receptor proteins and proteins involved in intracellular signaling pathways. A large number of expressed receptor proteins and proteins involved in intracellular signal transduction was detected. Several G-protein-coupled receptor signal pathways were significantly enriched in their expression level, in particular receptors and signaling pathways involved in the control of blood flow. The enriched signaling pathways also include pathways involved in trafficking of crucial transport proteins like, monocarboxylate transporters, V-ATPase, and aquaporin. The data, therefore, suggest that the rete mirabile has the capacity to control swimbladder function by regulating blood flow and by modifying countercurrent multiplication.
在最近的一项研究中，在欧洲鳗鱼盐灌注的 rete mirabile 组织的转录组和蛋白质组中检测到了大量的转运蛋白。在这项研究中，重新分析了数据集，以寻找受体蛋白和参与细胞内信号转导途径的蛋白。检测到大量表达的受体蛋白和参与细胞内信号转导的蛋白。几种 G 蛋白偶联受体信号通路在其表达水平上显著富集，特别是参与控制血流的受体和信号通路。富集的信号通路还包括涉及关键转运蛋白（如单羧酸转运蛋白、V-ATPase 和水通道蛋白）运输的途径。因此，数据表明 rete mirabile 有通过调节血流和改变逆流倍增来控制鳔功能的能力。
