Hall A H, Rumack B H
Am Fam Physician. 1986 May;33(5):107-14.
Acetaminophen is a popular analgesic and antipyretic medication that has few side effects and little toxicity when used in recommended doses. With ingestion of overdose quantities, accumulation of toxic metabolites may cause hepatotoxicity. Acetylcysteine is an effective antidote when used early in the course of an acute overdose. An accurate history of the time of ingestion and an acetaminophen plasma level will determine which patients require treatment with acetylcysteine.
对乙酰氨基酚是一种常用的止痛和解热药物，按推荐剂量使用时副作用少且毒性小。过量摄入后，有毒代谢物的蓄积可能会导致肝毒性。在急性过量摄入的病程早期使用时，乙酰半胱氨酸是一种有效的解毒剂。准确的摄入时间病史和对乙酰氨基酚血浆水平将确定哪些患者需要使用乙酰半胱氨酸进行治疗。
