Department of Cell Biology and Molecular Medicine, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Newark, NJ, USA.
Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT, USA.
Dev Biol. 2023 Jul;499:10-21. doi: 10.1016/j.ydbio.2023.04.001. Epub 2023 Apr 14.
Development of the outflow tract of the heart requires specification, proliferation and deployment of a progenitor cell population from the second heart field to generate the myocardium at the arterial pole of the heart. Disruption of these processes leads to lethal defects in rotation and septation of the outflow tract. We previously showed that Fibroblast Growth Factor 8 (FGF8) directs a signaling cascade in the second heart field that regulates critical aspects of OFT morphogenesis. Here we show that in addition to the survival and proliferation cues previously described, FGF8 provides instructive and patterning information to OFT myocardial cells and their progenitors that prevents their aberrant differentiation along a working myocardial program.
心脏流出道的发育需要从第二心脏场中指定、增殖和部署祖细胞群体，以在心脏的动脉极生成心肌。这些过程的破坏导致流出道旋转和分隔的致命缺陷。我们之前表明，成纤维细胞生长因子 8（FGF8）在第二心脏场中指导信号级联反应，调节流出道形态发生的关键方面。在这里，我们表明，除了以前描述的存活和增殖线索外，FGF8 还为流出道心肌细胞及其祖细胞提供指导和模式信息，防止它们沿着工作心肌程序异常分化。
