溴莫尼定。

Brimonidine.

机构信息

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia; Department of Chemistry, Faculty of Science and Technology, Al-Neelain University, Khartoum, Sudan.

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.

出版信息

Profiles Drug Subst Excip Relat Methodol. 2023;48:1-37. doi: 10.1016/bs.podrm.2022.11.001. Epub 2023 Feb 24.

DOI:10.1016/bs.podrm.2022.11.001

PMID:37061271

Abstract

Brimonidine is a highly selective 2-adrenoceptor agonist that lowers intraocular pressure (IOP) by decreasing aqueous humor production and increasing aqueous humor outflow via the uveoscleral route. Brimonidine is used to treat glaucoma and other eye conditions. Brimonidine is a topical medication that is used mainly to treat open-angle glaucoma and ocular hypertension in the eyelids. The purpose of this chapter is to provide a comprehensive discussion of Brimonidine's nomenclature, physiochemical properties, preparation methods, identification procedures, and numerous qualitative and quantitative analytical techniques, as well as its ADME profiles and pharmacological effects. In addition, the chapter contains numerous approaches for separating brimonidine from other medications in combination formulations utilizing chromatographic techniques and other spectroscopic approaches.

摘要

溴莫尼定是一种高度选择性的 2 肾上腺素受体激动剂，通过减少房水生成和增加葡萄膜巩膜途径的房水流出来降低眼内压 (IOP)。溴莫尼定用于治疗青光眼和其他眼部疾病。溴莫尼定是一种局部用药物，主要用于治疗眼睑的开角型青光眼和眼内高压。本章的目的是全面讨论溴莫尼定的命名、物理化学性质、制备方法、鉴定程序以及众多定性和定量分析技术，以及它的 ADME 概况和药理作用。此外，本章还包含了利用色谱技术和其他光谱方法从组合配方中分离溴莫尼定的多种方法。