CRCM, Inserm, CNRS, Institut Paoli-Calmettes, Aix-Marseille Univeristy, Epithelial Stem Cells and Cancer Laboratory, Equipe Labellisée LIGUE Contre le Cancer, Marseille, France.
Institut Curie, PSL Research University, Sorbonne University, Paris, France.
Trends Cell Biol. 2023 Oct;33(10):887-897. doi: 10.1016/j.tcb.2023.03.010. Epub 2023 Apr 14.
Increase in lineage infidelity and/or imbalance is frequently observed around the earliest stage of breast tumor initiation. In response to disruption of homeostasis, differentiated cells can partially lose their identity and gain cellular plasticity, a process involving epigenome landscape remodeling. This increase of cellular plasticity may promote the malignant transformation of breast tumors and fuel their heterogeneity. Here, we review recent studies that have yield insights into important regulators of lineage integrity and mechanisms that trigger mammary epithelial lineage derail, and evaluate their impacts on breast tumor development.
在乳腺癌起始的最早阶段，谱系不忠实和/或失衡经常被观察到。为了应对体内平衡的破坏，分化细胞可以部分失去其身份并获得细胞可塑性，这一过程涉及到表观基因组景观重塑。这种细胞可塑性的增加可能促进了乳腺癌的恶性转化，并为其异质性提供了动力。在这里，我们回顾了最近的研究，这些研究深入了解了谱系完整性的重要调节因子和触发乳腺上皮谱系脱轨的机制，并评估了它们对乳腺肿瘤发展的影响。
