Department of Immunology, University Complutense of Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Molecular Immunology Research Center, Medical School, Tehran University of Medical Sciences, Tehran, Iran.
Hum Immunol. 2023 May-Jul;84(5-7):311-312. doi: 10.1016/j.humimm.2023.04.001. Epub 2023 Apr 14.
Yazd City (1,200,000 inhabitants) is placed in the middle of its Iran desert province and it was constructed on a oasis in ancient times.However,it was a central point on the Silk Road and merchants from both Asia and Mediterranean/European areas crossed through Yazd City.We have studied HLA-A,-B,-DRB1 and DQB1 alleles in Yazd population.Analysys of nine most frequent extended class I and class II haplotypes shows that four of them are specific of this population.The other six haplotypes are also found in Asian and Mediterranean populations in significant frequency. This supports that the nowadays relatively isolated in desert Yazd area also contains people that may bear HLA genes probably originated because of long lasting merchants route between Europe and Asia through the European/Asian Silk Road in addition to other HLA genes close to other Iranian populations, including Kurds.
亚兹德市（有 120 万居民）位于伊朗沙漠省份的中心地带，它建在古代的绿洲上。然而，它是丝绸之路的中心，来自亚洲和地中海/欧洲地区的商人都经过亚兹德市。我们已经研究了亚兹德人群中的 HLA-A、-B、-DRB1 和 DQB1 等位基因。对九个最常见的扩展 I 类和 II 类单体型的分析表明，其中四个是该人群特有的。其他六个单体型也以显著的频率存在于亚洲和地中海人群中。这表明，如今相对与世隔绝的沙漠亚兹德地区也有一些人可能携带 HLA 基因，这些基因可能是由于欧洲和亚洲之间长期的商路通过欧洲/亚洲丝绸之路而产生的，此外，还有一些 HLA 基因与包括库尔德人在内的其他伊朗人群接近。
