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SOHO 最新进展及后续问题:晚期 CTCL 系统性治疗的现代方法。

SOHO State-of-the-Art Updates and Next Questions: A Modern Approach to the Systemic Treatment of Advanced CTCL.

机构信息

Department of Medicine, University of California Irvine Medical Center, Orange, CA.

Department of Medicine, University of California Irvine Medical Center, Orange, CA; Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, CA.

出版信息

Clin Lymphoma Myeloma Leuk. 2023 Jun;23(6):401-409. doi: 10.1016/j.clml.2023.03.003. Epub 2023 Mar 17.

Abstract

The term cutaneous T-cell lymphoma (CTCL) is a general term for T-cell lymphomas that are found primarily in skin. The most common CTCL entities, mycosis fungoides and Sezary syndrome are incurable diseases with a plethora of conventional treatment options. In the past treatment options have been selected primarily according to stage. Given newer targeted therapies with varied response in different body compartments, we suggest a compartment-guided algorithm that may enhance response rates directing the selection of the most efficacious treatment options.

摘要

皮肤 T 细胞淋巴瘤(CTCL)是一个广义术语,用于指代主要发生在皮肤的 T 细胞淋巴瘤。蕈样真菌病和 Sezary 综合征是最常见的 CTCL 实体,它们是无法治愈的疾病,有大量的常规治疗选择。过去,治疗选择主要根据分期进行。鉴于不同身体部位对不同靶向治疗的反应不同,我们建议采用基于部位的算法,这可能会提高反应率,指导选择最有效的治疗方法。

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