Division of Neonatology, Department of Pediatrics, MetroHealth Medical Center, Cleveland, Ohio, USA.
Department of Populations and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Neonatology. 2023;120(4):532-536. doi: 10.1159/000529850. Epub 2023 Apr 14.
Hypertensive disorders of pregnancy cause fetal growth restriction and increased maternal morbidity and mortality, especially in women of African ancestry. Recently, preeclampsia risk was associated with polymorphisms in the apolipoprotein L1 (APOL1) gene in women of African ancestry.
We assessed APOL1 genotype effects on pregnancies with and without preeclampsia.
We conducted an unmatched case-control study of 1,358 mother-infant pairs from two independent cohorts of black women.
Term preeclampsia cases with high-risk APOL1 genotypes were more likely to be small for gestational age compared to APOL1 low-risk term cases (odds ratio [OR] 2.8) and APOL1 high-risk controls (OR 5.5). Among preterm pregnancies, fetal APOL1 genotype was associated with preeclampsia.
Fetal APOL1 genotype was associated with preeclampsia in preterm infants and with altered fetal growth in term infants. This may indicate APOL1 genotype impacts a spectrum of pregnancy complications mediated by a common pathophysiological event of placental insufficiency.
妊娠高血压疾病可导致胎儿生长受限以及孕产妇发病率和死亡率增加，尤其是在非裔美国女性中。最近，先兆子痫的风险与非裔美国女性载脂蛋白 L1（APOL1）基因的多态性有关。
评估 APOL1 基因型对合并和不合并先兆子痫的妊娠的影响。
我们对来自两个独立的黑人女性队列的 1358 对母婴进行了一项不成对的病例对照研究。
具有高危 APOL1 基因型的足月先兆子痫病例与低危 APOL1 足月病例（比值比 [OR] 2.8）和高危 APOL1 对照组相比，更有可能是小于胎龄儿（OR 5.5）。在早产妊娠中，胎儿 APOL1 基因型与先兆子痫有关。
胎儿 APOL1 基因型与早产婴儿的先兆子痫以及足月婴儿的胎儿生长受限有关。这可能表明，APOL1 基因型通过胎盘功能不全这一共同的病理生理事件，影响一系列妊娠并发症。
