Phologolo Thabo, Matshaba Mogomotsi, Mathuba Bathusi, Mokete Keboletse, Tshume Ontibile, Lowenthal Elizabeth
Department of Family Medicine and Public Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana.
Botswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
South Afr J HIV Med. 2023 Mar 28;24(1):1455. doi: 10.4102/sajhivmed.v24i1.1455. eCollection 2023.
Cervical cancer burden and prevalence of precursor lesions is unknown among young women living with HIV in high prevalence settings. Current cervical cancer screening guidelines in resource-limited settings with high HIV prevalence typically exclude adolescents and young women. After observing two cases of advanced cervical cancer among young women with perinatally acquired HIV, a pilot screening programme was established in Botswana.
To compare the prevalence of cervical abnormalities in young women with perinatally acquired HIV with women aged 30-49 years, regardless of HIV status.
We conducted a cross-sectional study of 30-49-year-old women who had visual inspection with acetic acid screening through the Botswana public sector programme, and youth (aged 15-24 years) with perinatally acquired HIV, at a single referral site between 2016 and 2018. We describe the prevalence of cervical abnormalities in each group as well as the crude prevalence ratio.
The prevalence of cervical abnormalities in women 30-49 years of age was 10.9% (95% confidence interval [CI]: 10.4, 11.4), and 10.1% (95% CI: 4.7, 18.3) for youth. The crude prevalence ratio was 1.07 (95% CI: 0.58, 2.01).
Inclusion of youth living with HIV in cervical cancer screening services should be considered in settings with a high prevalence of HIV and cervical cancer.
在艾滋病病毒高流行地区，感染艾滋病病毒的年轻女性的宫颈癌负担和癌前病变患病率尚不清楚。在艾滋病病毒高流行的资源有限地区，目前的宫颈癌筛查指南通常将青少年和年轻女性排除在外。在观察到两例围产期感染艾滋病病毒的年轻女性患晚期宫颈癌后，博茨瓦纳开展了一项试点筛查项目。
比较围产期感染艾滋病病毒的年轻女性与30 - 49岁女性（无论艾滋病病毒感染状况如何）的宫颈异常患病率。
2016年至2018年期间，我们在一个转诊点对通过博茨瓦纳公共部门项目接受醋酸目视检查筛查的30 - 49岁女性以及围产期感染艾滋病病毒的青年（15 - 24岁）进行了一项横断面研究。我们描述了每组宫颈异常的患病率以及粗患病率比。
30 - 49岁女性的宫颈异常患病率为10.9%（95%置信区间[CI]：10.4, 11.4），青年的患病率为10.1%（95% CI：4.7, 18.3）。粗患病率比为1.07（95% CI：0.58, 2.01）。
在艾滋病病毒和宫颈癌高流行地区，应考虑将感染艾滋病病毒的青年纳入宫颈癌筛查服务。
