钙通道阻滞剂（硝苯地平）对妊娠山羊子宫血流的影响。

The effect of a calcium channel blocker (nifedipine) on uterine blood flow in the pregnant goat.

作者信息

Veille J C, Bissonnette J M, Hohimer A R

出版信息

Am J Obstet Gynecol. 1986 May;154(5):1160-3. doi: 10.1016/0002-9378(86)90779-9.

Abstract

The purpose of this study was to analyze the changes in maternal uterine blood flow, maternal arterial blood pressure, and maternal heart rate with the intravenous administration of nifedipine in pregnant, unanesthetized pygmy goats. Bolus injections of 2.5 to 45 micrograms/kg of maternal weight were used. Uterine blood flow did not fall significantly. A transient fall in maternal arterial blood pressure occurred in the first minute after the injection, but the pressure returned to normal after 5 minutes. Maternal heart rate increased immediately after the bolus of nifedipine and returned toward the control value by 30 minutes.

摘要

本研究的目的是分析在未麻醉的怀孕侏儒山羊中静脉注射硝苯地平后母体子宫血流量、母体动脉血压和母体心率的变化。使用的推注剂量为每千克母体体重2.5至45微克。子宫血流量没有显著下降。注射后第一分钟母体动脉血压出现短暂下降，但5分钟后血压恢复正常。推注硝苯地平后母体心率立即增加，并在30分钟时恢复至接近对照值。