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抢救性硬膜外生理盐水注射治疗难治性凸面自发性亚急性硬膜下血肿昏迷患者:病例报告

Rescue Epidural Saline Patch for Comatose Patients With Refractory Convexity Spontaneous Subacute Subdural Hematoma: Case Report.

作者信息

Roy Mickaela, Welschbillig Stephane, Cantier Marie, Chauvet Dorian, Bourdillon Pierre, Engrand Nicolas

机构信息

Intensive Care Unit - Anesthesiology (MR, SW, MC, NE), Rothschild Foundation Hospital; Neurosurgery Department (DC, PB), Rothschild Foundation Hospital.

出版信息

Neurol Clin Pract. 2023 Apr;13(2):e200137. doi: 10.1212/CPJ.0000000000200137. Epub 2023 Mar 10.

Abstract

OBJECTIVES

Convexity spontaneous subacute subdural hematoma (CSSSH) frequently relapse after one or more surgical drainages. This may be due to spontaneous intracranial hypotension (SIH), for which the gold standard treatment is the epidural blood patch. In this study, we report 4 cases of refractory CSSSH treated with rescue epidural saline patch, although history and imaging studies showed no evidence of SIH.

METHODS

All 4 patients received a lumbar saline epidural rescue patch for consciousness impairment associated with refractory CSSSH, and one is particularly detailed. No patient had typical radiologic signs of SIH or, on the contrary, uncal herniation that could have indicated intracranial hypertension.

RESULTS

The Glasgow Coma Scale score improved significantly in the days after application of the epidural patch in 3 patients. All patients showed an improvement of the CT scan. Two patients underwent lumbar pressure measurement to confirm low values before the epidural injection, and for one, the intrathecal pressure profile during epidural patching is presented.

DISCUSSION

An epidural patch may be considered in managing CSSSH with no uncal herniation, even in the absence of signs of SIH on brain and spinal imaging. Whether it should be combined with surgical evacuation or used as first-line therapy remains to be determined.

摘要

目的

凸面自发性亚急性硬膜下血肿(CSSSH)在一次或多次手术引流后常复发。这可能是由于自发性颅内低压(SIH)所致,其金标准治疗方法是硬膜外血补丁。在本研究中,我们报告了4例难治性CSSSH患者,尽管病史和影像学检查未显示SIH证据,但采用了挽救性硬膜外盐水补丁治疗。

方法

所有4例患者均因难治性CSSSH相关的意识障碍接受了腰椎硬膜外盐水挽救性补丁治疗,其中1例尤为详细。没有患者有典型的SIH放射学征象,相反,也没有提示颅内高压的小脑幕切迹疝征象。

结果

3例患者在应用硬膜外补丁后的数天内格拉斯哥昏迷量表评分显著改善。所有患者的CT扫描均有改善。2例患者在硬膜外注射前进行了腰椎压力测量以确认低值,其中1例展示了硬膜外补丁治疗期间的鞘内压力曲线。

讨论

即使在脑部和脊髓影像学上没有SIH征象,对于没有小脑幕切迹疝的CSSSH患者,也可考虑使用硬膜外补丁治疗。它是否应与手术清除联合使用或作为一线治疗方法仍有待确定。

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