Abudeif Ahmed, Hashim Marwa S, Ahmed Nesma M, Ahmed Ahmed Othman
Department of Tropical Medicine and Gastroenterology, Sohag Faculty of Medicine, Sohag University, Egypt.
Department of Medical Biochemistry, Sohag Faculty of Medicine, Sohag University, Egypt.
Clin Exp Hepatol. 2023 Mar;9(1):71-78. doi: 10.5114/ceh.2023.125970. Epub 2023 Mar 21.
We aimed to investigate the possible association between serum copeptin and complications of liver cirrhosis, including its potential role as a stress biomarker in spontaneous bacterial peritonitis (SBP).
This cross-sectional study included 89 cirrhotic ascitic patients (37 with SBP and 52 without SBP) admitted to Sohag University Hospitals, Egypt, between June 2021 and February 2022. Serum copeptin was measured in all patients, and its association with SBP and other complications of liver cirrhosis was investigated.
Serum copeptin was significantly elevated in patients with SBP compared to those without SBP ( = 0.032) and significantly correlated with ascitic fluid study parameters, systemic inflammatory markers, and liver, renal, and circulatory functions. Serum copeptin and C-reactive protein (CRP) were independent risk factors for the presence of SBP. Serum copeptin detects SBP at a cut-off value of 9 pmol/l, with sensitivity and specificity of 73% and 64%, respectively. Serum copeptin was significantly associated with hepatic encephalopathy, gastrointestinal bleeding, hepatorenal syndrome, and larger amounts of ascites.
Serum copeptin is an independent risk factor for the presence of SBP and significantly increased in patients presented with major complications of liver cirrhosis, demonstrating its ability to reflect circulatory dysfunction and systemic inflammation.
我们旨在研究血清 copeptin 与肝硬化并发症之间的可能关联，包括其作为自发性细菌性腹膜炎（SBP）应激生物标志物的潜在作用。
这项横断面研究纳入了 2021 年 6 月至 2022 年 2 月期间入住埃及索哈杰大学医院的 89 例肝硬化腹水患者（37 例有 SBP，52 例无 SBP）。对所有患者测定血清 copeptin，并研究其与 SBP 和肝硬化其他并发症的关联。
与无 SBP 的患者相比，有 SBP 的患者血清 copeptin 显著升高（P = 0.032），且与腹水研究参数、全身炎症标志物以及肝脏、肾脏和循环功能显著相关。血清 copeptin 和 C 反应蛋白（CRP）是 SBP 存在的独立危险因素。血清 copeptin 在截断值为 9 pmol/l 时可检测出 SBP，敏感性和特异性分别为 73%和 64%。血清 copeptin 与肝性脑病、胃肠道出血、肝肾综合征以及大量腹水显著相关。
血清 copeptin 是 SBP 存在的独立危险因素，在出现肝硬化主要并发症的患者中显著升高，表明其能够反映循环功能障碍和全身炎症。
