Department of Otolaryngology, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
Theranostics. 2023 Mar 16;13(6):1823-1825. doi: 10.7150/thno.83486. eCollection 2023.
Gene expression network in cancer cells is orchestrated by a small number of master regulator transcription factors (MRTFs), which play a prominent role in regulating cancer intrinsic hallmarks, such as sustaining proliferative signaling, evading growth suppressors, resisting cell death, etc. A new study reports a new role of one MRTF, KLF5, in regulating tumor microenvironment in an extrinsic manner. These findings not only reveal novel mechanistic underpinnings of tumor evasion from immune destruction but also broaden our understanding of the transcriptional deregulation in cancer biology.
癌细胞中的基因表达网络是由少数几个主要调节转录因子（MRTFs）协调的，这些转录因子在调节癌症内在特征方面发挥着重要作用，如维持增殖信号、逃避生长抑制物、抵抗细胞死亡等。一项新的研究报告了一个 MRTF，即 KLF5，以一种外在的方式调节肿瘤微环境的新作用。这些发现不仅揭示了肿瘤逃避免疫破坏的新机制基础，也拓宽了我们对癌症生物学中转录失调的理解。
