Joseph Andrew M, Karas Monica, Jara Silva Cesar E, Leyva Melissa, Salam Abdus, Sinha Mehul, Asfaw Yonathan Aliye, Fonseca Ayesha, Cordova Steven, Reyes Marlon, Quinonez Jonathan, Ruxmohan Samir
Osteopathic Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Davie, USA.
Osteopathic Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA.
Cureus. 2023 Mar 15;15(3):e36185. doi: 10.7759/cureus.36185. eCollection 2023 Mar.
Strokes are the second leading cause of death and disability worldwide. The brain injury resulting from stroke produces a persistent neuroinflammatory response in the brain, resulting in a spectrum of neurologic dysfunction affecting stroke survivors chronically, also known as post-stroke pain. Excess production of tumor necrosis factor alpha (TNF alpha) in the cerebrospinal fluid (CSF) of stroke survivors has been implicated in post-stroke pain. Therefore, this literature review aims to assess and review the role of perispinal etanercept in the management of post-stroke pain. Several studies have shown statistically significant evidence that etanercept, a TNF alpha inhibitor, can reduce symptoms present in post-stroke syndrome by targeting the excess TNF alpha produced in the CSF. Studies have also shown improvements in not only post-stroke pain but also in traumatic brain injury and dementia. Further research is needed to explore the effects of TNF alpha on stroke prognosis and determine the optimal frequency and duration of etanercept treatment for post-stroke pain.
中风是全球第二大致死和致残原因。中风导致的脑损伤会在大脑中引发持续的神经炎症反应，导致一系列长期影响中风幸存者的神经功能障碍，即所谓的中风后疼痛。中风幸存者脑脊液（CSF）中肿瘤坏死因子α（TNFα）的过度产生与中风后疼痛有关。因此，本综述旨在评估和综述脊柱周围注射依那西普在中风后疼痛管理中的作用。多项研究已显示具有统计学意义的证据表明，TNFα抑制剂依那西普可通过靶向脑脊液中产生的过量TNFα来减轻中风后综合征的症状。研究还表明，依那西普不仅能改善中风后疼痛，还能改善创伤性脑损伤和痴呆症状。需要进一步研究来探索TNFα对中风预后的影响，并确定依那西普治疗中风后疼痛的最佳频率和持续时间。
