INTRODUCTION

Malignant pancreatic cancer has poor long-term survival. Increasing evidence shows that (family with sequence similarity 83 member A) plays a vital role in tumorigenesis and malignant progression in some human cancer types. The present study explored the potential mechanism of in improving the prognosis of pancreatic cancer patients.

METHODS

Transcriptomic and clinical data from patients were obtained from The Cancer Genome Atlas while expression was measured in tumorous pancreatic tissue compared with normal controls by quantitative real-time PCR and immunohistochemistry.

RESULTS

is a vital prognostic indicator and potential oncogene in pancreatic cancer via pan-cancer analysis. analysis revealed that AL049555.1/hsa-miR-129-5p axis was the pivotal upstream ncRNA- mediated pathway of in pancreatic cancer. Furthermore, expression was related to immune cell infiltration through vital immune-related genes including , and tumorigenesis through common mutation genes including , and . In summary, ncRNA-mediated upregulation of is associated with poor long-term survival and immune cell infiltration in pancreatic cancer.

DISCUSSION

may be used as a novel survival-related and immune-related biomarker. This information suggests that may be a novel therapeutic target for combined or individual treatment for patients with pancreatic cancer.