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ncRNA 介导的上调与胰腺癌不良预后和免疫浸润相关。

ncRNA-mediated upregulation of is associated with poor prognosis and immune infiltration in pancreatic cancer.

机构信息

Department of General Surgery, No.924 Hospital of PLA Joint Logistic Support Force, Guilin, China.

Neurology Department, No.924 Hospital of PLA Joint Logistic Support Force, Guilin, China.

出版信息

Front Endocrinol (Lausanne). 2023 Mar 31;14:1093042. doi: 10.3389/fendo.2023.1093042. eCollection 2023.

DOI:10.3389/fendo.2023.1093042
PMID:37065746
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10102663/
Abstract

INTRODUCTION

Malignant pancreatic cancer has poor long-term survival. Increasing evidence shows that (family with sequence similarity 83 member A) plays a vital role in tumorigenesis and malignant progression in some human cancer types. The present study explored the potential mechanism of in improving the prognosis of pancreatic cancer patients.

METHODS

Transcriptomic and clinical data from patients were obtained from The Cancer Genome Atlas while expression was measured in tumorous pancreatic tissue compared with normal controls by quantitative real-time PCR and immunohistochemistry.

RESULTS

is a vital prognostic indicator and potential oncogene in pancreatic cancer via pan-cancer analysis. analysis revealed that AL049555.1/hsa-miR-129-5p axis was the pivotal upstream ncRNA- mediated pathway of in pancreatic cancer. Furthermore, expression was related to immune cell infiltration through vital immune-related genes including , and tumorigenesis through common mutation genes including , and . In summary, ncRNA-mediated upregulation of is associated with poor long-term survival and immune cell infiltration in pancreatic cancer.

DISCUSSION

may be used as a novel survival-related and immune-related biomarker. This information suggests that may be a novel therapeutic target for combined or individual treatment for patients with pancreatic cancer.

摘要

简介

恶性胰腺癌症的长期生存预后较差。越来越多的证据表明，在某些人类癌症类型中，（家族与序列相似性 83 成员 A）在肿瘤发生和恶性进展中起着至关重要的作用。本研究探讨了在改善胰腺癌症患者预后方面的潜在机制。

方法

从癌症基因组图谱中获取患者的转录组和临床数据，同时通过定量实时 PCR 和免疫组织化学法比较肿瘤胰腺组织与正常对照中的表达。

结果

通过泛癌症分析，是胰腺癌症中重要的预后指标和潜在的癌基因。分析表明，AL049555.1/hsa-miR-129-5p 轴是胰腺癌症中 关键的上游 ncRNA 介导途径。此外，通过包括、等重要免疫相关基因，以及包括、等常见突变基因，表达与免疫细胞浸润相关。总的来说，ncRNA 介导的上调与胰腺癌症患者的不良长期生存和免疫细胞浸润有关。

讨论

可能是一种新的与生存和免疫相关的生物标志物。这些信息表明，可能是一种用于治疗胰腺癌症患者的联合或单独治疗的新的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2290/10102663/8f86d47ee8ec/fendo-14-1093042-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2290/10102663/cb4798072837/fendo-14-1093042-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2290/10102663/eb8ff303a47b/fendo-14-1093042-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2290/10102663/95ecfea6df63/fendo-14-1093042-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2290/10102663/8fa0b5b679a3/fendo-14-1093042-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2290/10102663/264fa3cac13e/fendo-14-1093042-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2290/10102663/8780127d8766/fendo-14-1093042-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2290/10102663/c49a6630a533/fendo-14-1093042-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2290/10102663/8f86d47ee8ec/fendo-14-1093042-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2290/10102663/cb4798072837/fendo-14-1093042-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2290/10102663/eb8ff303a47b/fendo-14-1093042-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2290/10102663/95ecfea6df63/fendo-14-1093042-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2290/10102663/8fa0b5b679a3/fendo-14-1093042-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2290/10102663/264fa3cac13e/fendo-14-1093042-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2290/10102663/8780127d8766/fendo-14-1093042-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2290/10102663/c49a6630a533/fendo-14-1093042-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2290/10102663/8f86d47ee8ec/fendo-14-1093042-g008.jpg

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Future Oncol. 2021 Nov;17(31):4131-4143. doi: 10.2217/fon-2021-0495. Epub 2021 Aug 4.
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