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用于磁共振成像引导的近红外光热疗法的多巴胺多价修饰聚天冬氨酸

Dopamine multivalent-modified polyaspartic acid for MRI-guided near-infrared photothermal therapy.

作者信息

Du Liang, Chen Wei, Zhong Jie, Yan Shuang, Yang Chenwu, Pu Yu, Zhu Jiang, Chen Tianwu, Zhang Xiaoming, Wu Changqiang

机构信息

Medical Imaging Key Laboratory of Sichuan Province and School of Medical Imaging, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, PR China.

出版信息

Regen Biomater. 2023 Mar 14;10:rbad022. doi: 10.1093/rb/rbad022. eCollection 2023.

DOI:10.1093/rb/rbad022
PMID:37066094
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10097457/
Abstract

Nanophotothermal agents that provide efficient and precise treatment at tumor sites are attracting increasing attention in biomedicine. In particular, the method combination of nanophotothermal agents and magnetic resonance imaging (MRI) shows great promise for biomedical therapeutic applications. Herein, a simple nanophotothermal agent with dopamine multivalent-modified polyaspartic acid chelated superparamagnetic iron oxide (SPIO) and ferric ion (SPIO@PAsp-DAFe/PEG) was developed for MRI-guided near-infrared photothermal therapy (PTT). SPIO@PAsp-DAFe/PEG was random SPIO nanocluster with good water solubility, had a diameter of 57.8 ± 7.8 nm in dynamic light scattering, negatively charged surface (zeta potential = -11 mV), exhibited good stability and outstanding photothermal conversion efficiency (35.4%) and produced superior magnetic resonance enhanced imaging. In the experiment with tumor-bearing mice, the MRI not only monitored the accumulation of SPIO@PAsp-DAFe/PEG nanocomposites enhanced by near-infrared irradiation after intravenous administration but also determined the appropriate time window for PTT. With the use of MRI-guided near-infrared therapy, the SPIO@PAsp-DAFe/PEG nanocomposites provided excellent therapeutic effects, confirming their great potential as effective MRI/PTT therapeutic agents.

摘要

能够在肿瘤部位提供高效精确治疗的纳米光热剂在生物医学领域正受到越来越多的关注。特别是，纳米光热剂与磁共振成像（MRI）的方法组合在生物医学治疗应用中显示出巨大的潜力。在此，开发了一种简单的纳米光热剂，其为多巴胺多价修饰的聚天冬氨酸螯合超顺磁性氧化铁（SPIO）和铁离子（SPIO@PAsp-DAFe/PEG），用于MRI引导的近红外光热疗法（PTT）。SPIO@PAsp-DAFe/PEG是具有良好水溶性的随机SPIO纳米簇，动态光散射直径为57.8±7.8nm，表面带负电（zeta电位=-11mV），表现出良好的稳定性和出色的光热转换效率（35.4%），并产生优异的磁共振增强成像。在荷瘤小鼠实验中，MRI不仅监测了静脉注射后近红外照射增强的SPIO@PAsp-DAFe/PEG纳米复合材料的积累情况，还确定了PTT的合适时间窗口。通过使用MRI引导的近红外疗法，SPIO@PAsp-DAFe/PEG纳米复合材料提供了优异的治疗效果，证实了它们作为有效的MRI/PTT治疗剂的巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/350d/10097457/dd60e7a2efcb/rbad022f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/350d/10097457/b243fc3c6ccd/rbad022f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/350d/10097457/f400cf2e39eb/rbad022f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/350d/10097457/ca1a09901bbd/rbad022f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/350d/10097457/b1db81d765f7/rbad022f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/350d/10097457/57abaeda1582/rbad022f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/350d/10097457/1d46cae6711e/rbad022f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/350d/10097457/4b00f1c460b0/rbad022f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/350d/10097457/dd60e7a2efcb/rbad022f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/350d/10097457/b243fc3c6ccd/rbad022f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/350d/10097457/f400cf2e39eb/rbad022f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/350d/10097457/ca1a09901bbd/rbad022f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/350d/10097457/b1db81d765f7/rbad022f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/350d/10097457/57abaeda1582/rbad022f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/350d/10097457/1d46cae6711e/rbad022f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/350d/10097457/4b00f1c460b0/rbad022f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/350d/10097457/dd60e7a2efcb/rbad022f7.jpg

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Dopamine multivalent-modified polyaspartic acid for MRI-guided near-infrared photothermal therapy.

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本文引用的文献

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Nanoscale. 2021-11-25

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Designing highly stable ferrous selenide-black phosphorus nanosheets heteronanostructure via P-Se bond for MRI-guided photothermal therapy.

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