Key Laboratory for Organic Electronics and Information Displays (KLOEID) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China.
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China.
Theranostics. 2019 May 31;9(14):4168-4181. doi: 10.7150/thno.34390. eCollection 2019.
Our exploiting versatile multimodal theranostic agent aims to integrate the complementary superiorities of photoacoustic imaging (PAI), second near-infrared (NIR-II, 1000-1700) fluorescence and T-weighted magnetic resonance imaging (MRI) with an ultimate objective of perfecting cancer diagnosis, thus improving cancer therapy efficacy. Herein, we engineered and prepared a water-soluble gadolinium-chelated conjugated polymer-based theranostic nanomedicine (PFTQ-PEG-Gd NPs) for in vivo tri-mode PA/MR/NIR-II imaging-guided tumor photothermal therapy (PTT). : We firstly constructed a semiconducting polymer composed of low-bandgap donor-acceptor (D-A) which afforded the strong NIR absorption for PAI/PTT and long fluorescence emission to NIR-II region for in vivo imaging. Then, the remaining carboxyl groups of the polymeric NPs could effectively chelate with Gd ions for MRI. The in vitro characteristics of the PFTQ-PEG-Gd NPs were studied and the in vivo multimode imaging as well as anti-tumor efficacy of the NPs was evaluated using 4T1 tumor-bearing mice. : The obtained theranostic agent showed excellent chemical and optical stability as well as low biotoxicity. After 24 h of systemic administration using PQTF-PEG-Gd NPs, the tumor sites of living mice exhibited obvious enhancement in PA, NIR-II fluorescence and positive MR signal intensities. Better still, a conspicuous tumor growth restraint was detected under NIR light irradiation after administration of PQTF-PEG-Gd NPs, indicating the efficient photothermal potency of the nano-agent. : we triumphantly designed and synthesized a novel and omnipotent semiconducting polymer nanoparticles-based theranostic platform for PAI, NIR-II fluorescence imaging as well as positive MRI-guided tumor PTT in living mice. We expect that such a novel organic nano-platform manifests a great promise for high spatial resolution and deep penetration cancer theranostics.
我们开发的多功能多模式治疗剂旨在整合光声成像（PAI）、近红外二区（NIR-II，1000-1700nm）荧光和 T 加权磁共振成像（MRI）的互补优势，最终目标是完善癌症诊断，从而提高癌症治疗效果。在此，我们设计并制备了一种基于水溶性镧系元素螯合共轭聚合物的治疗性纳米药物（PFTQ-PEG-Gd NPs），用于体内三模式 PA/MR/NIR-II 成像引导肿瘤光热治疗（PTT）。
我们首先构建了一种由低带隙给体-受体（D-A）组成的半导体聚合物，该聚合物赋予 PAI/PTT 强近红外吸收和长荧光发射到近红外二区（NIR-II），用于体内成像。然后，聚合物 NPs 中剩余的羧基可有效与 Gd 离子螯合用于 MRI。我们研究了 PFTQ-PEG-Gd NPs 的体外特性，并通过 4T1 荷瘤小鼠评估了 NPs 的体内多模式成像和抗肿瘤疗效。
所得到的治疗剂表现出优异的化学和光学稳定性以及低生物毒性。静脉注射 PQTF-PEG-Gd NPs 24 小时后，活鼠的肿瘤部位在 PA、NIR-II 荧光和阳性 MR 信号强度上均有明显增强。更重要的是，在注射 PQTF-PEG-Gd NPs 后经近红外光照射，明显抑制了肿瘤的生长，表明纳米剂具有高效的光热性能。
我们成功设计并合成了一种新型多功能半导体聚合物纳米粒子治疗平台，用于 PAI、NIR-II 荧光成像以及活体小鼠的正 MRI 引导肿瘤 PTT。我们期望这种新型有机纳米平台在高空间分辨率和深穿透癌症治疗方面具有广阔的应用前景。
Zotero 插件
