National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
Department of Urology, South China Hospital, Medical School, Shenzhen University, Shenzhen, P.R. China.
Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231169873. doi: 10.1177/15330338231169873.
Esophageal cancer is one of the most lethal malignancies worldwide. For locally advanced diseases, radiotherapy is the main treatment. The survival rates, however, are still appalling, which is partially due to radioresistance. In 6% of cases of esophageal cancer, the Hedgehog pathway is reactivated, and this pathway is crucial for the growth, progression, treatment resistance, and metastasis of esophageal cancer. Here, we conducted a comprehensive review of the current research on Hedgehog pathway in esophageal cancer.
食管癌是全球最致命的恶性肿瘤之一。对于局部晚期疾病，放射治疗是主要治疗方法。然而，生存率仍然令人震惊，部分原因是放射抵抗。在 6%的食管癌病例中，Hedgehog 通路被重新激活，该通路对于食管癌的生长、进展、治疗抵抗和转移至关重要。在这里，我们对 Hedgehog 通路在食管癌中的研究进行了全面综述。
