The Department of Scientific Education, The First People's Hospital of Jiande, Jiande, Hangzhou, Zhejiang, China.
Institute of Regenerative Biology and Medicine, Helmholtz Center Munich, Munich, Germany.
Int J Dermatol. 2023 Jul;62(7):952-961. doi: 10.1111/ijd.16673. Epub 2023 Apr 17.
Cutaneous angiosarcoma (cAS) is a rare and not well-established malignant neoplasm characterized by dismal prognosis. Treatment for cAS remains controversial.
From 1975 to 2016, a total of 872 patients with cAS (379 secondary cAS [s-cAS] patients and 493 de novo cAS [dn-cAS]) patients were identified from the Surveillance, Epidemiology, and End Results (SEER) database.
Survival analyses were performed utilizing Kaplan-Meier curves and Cox proportional hazards regression models.
Both the number of s-cAS patients and dn-cAS patients climbed steadily over 42 years. There is a gradual increase in the proportion of s-cAS among whole cAS patients for each interval, ranging from 0% to 51.2%.Taking into account a combination of Kaplan-Meier and Cox regression methods, the survival of s-cAS is similar to dn-cAS. On multivariate analysis, older age, greater tumor size, primary site located at lower extremity, advanced stage, and no surgery were independent prognostic factors of decreased overall survival (OS) in both the s-cAS and dn-cAS groups.
Apparent increase in the number of s-cAS patients requires further attention. Surgery is still recommended for the treatment of both s-cAS and dn-cAS patients, and the requirement for treatment improvement is imperative.
皮肤血管肉瘤（cAS）是一种罕见且尚未确立的恶性肿瘤，预后较差。cAS 的治疗仍存在争议。
本研究从 1975 年至 2016 年，从监测、流行病学和最终结果（SEER）数据库中确定了 872 例 cAS（379 例继发性 cAS[s-cAS]患者和 493 例原发性 cAS[dn-cAS]患者）。
采用 Kaplan-Meier 曲线和 Cox 比例风险回归模型进行生存分析。
42 年来，s-cAS 患者和 dn-cAS 患者的数量均稳步上升。在每个时间段，s-cAS 在所有 cAS 患者中的比例逐渐增加，从 0%到 51.2%不等。考虑到 Kaplan-Meier 和 Cox 回归方法的结合，s-cAS 的生存与 dn-cAS 相似。多变量分析显示，年龄较大、肿瘤较大、原发部位位于下肢、晚期和无手术是 s-cAS 和 dn-cAS 两组患者总生存（OS）降低的独立预后因素。
s-cAS 患者数量的明显增加需要进一步关注。手术仍然是 s-cAS 和 dn-cAS 患者治疗的推荐方法，迫切需要改善治疗效果。
