Niccolò Cusano University, Rome, Italy.
Laboratory of Neuropsychology of Memory, Department of Clinical Neuroscience and Neurorehabilitation, IRCCS Santa Lucia Foundation, Rome, Italy.
J Neuropsychol. 2023 Sep;17(3):450-460. doi: 10.1111/jnp.12317. Epub 2023 Apr 17.
Here, we examined mechanisms that affect retrograde memory in amnestic mild cognitive impairment (a-MCI) as a function of longitudinal clinical outcome. 8 a-MCI who converted to Alzheimer's dementia (AD) during the subsequent 3-year follow-up (converter a-MCI) and 10 a-MCI who remained clinically stable during the same period (stable a-MCI) were compared at the baseline evaluation (i.e., when they were diagnosed as a-MCI) using a remote memory questionnaire for public events that allows disentangling the differential contribution of storage and retrieval mechanisms to performance accuracy. Results suggest that deficits in remote memory are primarily explained by impaired retrieval abilities in stable a-MCI and by impaired storage in converter-to-AD a-MCI. This distinction between retrograde amnesia due to defective trace utilisation in stable a-MCI and trace storage in converter a-MCI is consistent with the temporal unfolding of declining anterograde memory over the course of disease progression to AD.
在这里，我们研究了影响遗忘型轻度认知障碍 (a-MCI) 逆行性记忆的机制，这些机制是作为纵向临床结局的函数。在随后的 3 年随访中，8 名 a-MCI 转化为阿尔茨海默病（AD）（转化型 a-MCI），而在同一时期 10 名 a-MCI 保持临床稳定（稳定型 a-MCI），在基线评估时进行比较（即，当他们被诊断为 a-MCI 时），使用公共事件的远程记忆问卷，该问卷允许区分存储和检索机制对性能准确性的不同贡献。结果表明，稳定型 a-MCI 中远程记忆的缺陷主要是由于检索能力受损，而在转化为 AD 的 a-MCI 中则是由于存储能力受损。稳定型 a-MCI 中由于痕迹利用缺陷导致逆行性遗忘和转化型 a-MCI 中由于痕迹存储导致逆行性遗忘之间的这种区别与疾病进展为 AD 过程中顺行性记忆逐渐下降的时间展开一致。
