Martinez Daniela de Abreu E Silva, Lupi Omar, D'Ácri Antônio Macedo
Department of Dermatology, Gaffree & Guinle University Hospital, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Brazil.
Indian J Dermatol Venereol Leprol. 2023 Sep-Oct;89(5):725-728. doi: 10.25259/IJDVL_902_2021.
Background People affected by Human Immunodeficiency Virus (HIV), are burdened by a higher risk of developing malignancies including non-melanoma skin cancer (NMSC) and melanoma skin cancer. Objective To evaluate the association of HIV with melanoma and NMSC at a University Hospital. Methods This is a cross-sectional retrospective study of HIV-infected and a matched comparison group, analyzing the associations between skin cancer and HIV infection. Results Compared to the HIV-uninfected, HIV-infected had 80% association with skin cancer (CI 95%: 1.3-2.4, P = 0.001) The risk was 45-fold higher by patients" age (CI 95%: 3.3-15.9: P = 0.001). When adjusted for patient age, sex and race, the risk was 6.4 fold ligher of having cancer if compared to the others (CI 95%: 49-84, P = 0.001). Melanoma was not found in HIV-infected. Conclusion With this study, we have demonstrated that HIV-infected patients have an increased risk of BCC and SCC. Preventive dermatologic management is pivotal in the care of immunosuppressed patients. These patients must undergo the dermatological examination annually and should receive extensive counseling regarding sun avoidance, use of sunscreens,and sun-protective clothing.
感染人类免疫缺陷病毒（HIV）的人群患包括非黑色素瘤皮肤癌（NMSC）和黑色素瘤皮肤癌在内的恶性肿瘤的风险更高。
评估在一家大学医院中HIV与黑色素瘤和NMSC之间的关联。
这是一项对HIV感染者和匹配对照组的横断面回顾性研究，分析皮肤癌与HIV感染之间的关联。
与未感染HIV的人相比，感染HIV的人与皮肤癌的关联度为80%（95%置信区间：1.3 - 2.4，P = 0.001）。风险随患者年龄增加45倍（95%置信区间：3.3 - 15.9：P = 0.001）。在对患者年龄、性别和种族进行调整后，与其他人相比患癌风险降低6.4倍（95%置信区间：49 - 84，P = 0.001）。在感染HIV的患者中未发现黑色素瘤。
通过这项研究，我们证明了感染HIV的患者患基底细胞癌（BCC）和鳞状细胞癌（SCC）的风险增加。预防性皮肤管理在免疫抑制患者的护理中至关重要。这些患者必须每年接受皮肤科检查，并应接受关于避免日晒、使用防晒霜和防晒服装的广泛咨询。
