中国人群中非白内障青少年和成年人及白内障患者晶状体体积的分布及相关因素。
Distribution and associated factors of crystalline lens volume in noncataract adolescents and adults and patients with cataract in a Chinese population.
机构信息
From the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China (Chen, Ruan, Gu, Zhang, Liu, Luo); Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, Guangdong, China (Chen, Ruan, Gu, Zhang, Liu, Luo); Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, Guangdong, China (Chen, Ruan, Gu, Zhang, Liu, Luo).
出版信息
J Cataract Refract Surg. 2023 Aug 1;49(8):783-789. doi: 10.1097/j.jcrs.0000000000001194.
PURPOSE
To explore the distribution of lens volume (VOL) and its associated factors in noncataract adolescents and adults and patients with cataract in a Chinese population.
SETTING
Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
DESIGN
Cross-sectional study.
METHODS
1674 eyes from 1674 Chinese participants (690 adolescents and 363 adults without cataract, and 621 patients with cataract) aged from 7 to 90 years were included. Lens thickness (LT) and lens diameter (LD) were measured using swept-source anterior segment optical coherence tomography (SS-AS OCT) to calculate VOL. Axial length (AL) was measured by IOL-Master 700. Pearson correlation analysis and multivariate linear regression models were used to evaluate the potential associated factors of lens dimensions.
RESULTS
The mean VOL was 167.74 ± 12.18 mm 3 in noncataract adolescents, 185.20 ± 14.95 mm 3 in noncataract adults, and 226.10 ± 49.25 mm 3 in patients with cataract. VOL had no significant correlation with AL in patients with cataract ( P > .05), neither in noncataract adolescents nor noncataract adults, when adjusted with LT, LD, age, and sex ( P > .05). On the other hand, eyes with longer ALs tended to have smaller LTs and larger LDs in all groups (all P -trend < .05). Larger VOL was associated with older age in all groups (all P < .001).
CONCLUSIONS
A data set of VOLs in Chinese eyes over a wide age range was presented. It is inaccurate to predict VOL, LT, and LD solely according to AL. The direct measurement and calculation of VOL in vivo and the establishment of the normal range of VOL could help predict the size of lens capsular bag and plan cataract surgery.
目的
探讨中国人群中非白内障青少年和成年人以及白内障患者的晶状体体积（VOL）分布及其相关因素。
设置
中山大学中山眼科中心，中国广州。
设计
横断面研究。
方法
纳入 1674 只眼的 1674 名中国参与者（690 名青少年和 363 名无白内障成年人，以及 621 名白内障患者），年龄 7 至 90 岁。使用扫频源眼前节光学相干断层扫描（SS-AS OCT）测量晶状体厚度（LT）和晶状体直径（LD），以计算 VOL。眼轴（AL）由 IOL-Master 700 测量。采用 Pearson 相关分析和多元线性回归模型评估晶状体尺寸的潜在相关因素。
结果
无白内障青少年的平均 VOL 为 167.74±12.18mm3，无白内障成年人的平均 VOL 为 185.20±14.95mm3，白内障患者的平均 VOL 为 226.10±49.25mm3。当调整 LT、LD、年龄和性别后，白内障患者的 VOL 与 AL 无显著相关性（P＞.05），无白内障青少年和无白内障成年人的 VOL 也与 AL 无显著相关性（P＞.05）。另一方面，所有组中，AL 较长的眼睛倾向于具有较小的 LT 和较大的 LD（所有 P-趋势＜.05）。所有组中，较大的 VOL 与年龄较大相关（均 P＜.001）。
结论
提供了一个涵盖广泛年龄范围的中国眼睛 VOL 数据集。仅根据 AL 预测 VOL、LT 和 LD 是不准确的。体内直接测量和计算 VOL，并建立 VOL 的正常范围，有助于预测晶状体囊袋的大小并计划白内障手术。
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