Greenspan S L, Neer R M, Ridgway E C, Klibanski A
Ann Intern Med. 1986 Jun;104(6):777-82. doi: 10.7326/0003-4819-104-6-777.
To ascertain the effects of chronic hyperprolactinemia and testosterone deficiency on skeletal integrity in men, we measured forearm bone density and hormone concentrations in 18 men aged 30 to 79 who had prolactin-secreting pituitary tumors. We also measured vertebral bone density in 12 of the men. Patients with hyperprolactinemia had significant decreases in both forearm (p less than 0.001) and vertebral bone density (p = 0.003) compared with age-matched controls. Cortical osteopenia was significantly related to the duration of hyperprolactinemia (p less than 0.01) but not to the absolute levels of prolactin or androgens. Seven patients had longitudinal follow-up measurements of forearm bone density. Normalization of serum levels of prolactin or testosterone was associated with an increase in forearm bone density (p less than 0.05). These data show that chronic hyperprolactinemia and testosterone deficiency in men have deleterious and previously unrecognized extragonadal effects that may be alleviated after normalization of hormone concentrations.
为确定慢性高泌乳素血症和睾酮缺乏对男性骨骼完整性的影响，我们测量了18名年龄在30至79岁、患有分泌泌乳素的垂体瘤男性的前臂骨密度和激素浓度。我们还测量了其中12名男性的脊椎骨密度。与年龄匹配的对照组相比，高泌乳素血症患者的前臂骨密度（p<0.001）和脊椎骨密度（p = 0.003）均显著降低。皮质骨减少与高泌乳素血症的持续时间显著相关（p<0.01），但与泌乳素或雄激素的绝对水平无关。7名患者接受了前臂骨密度的纵向随访测量。泌乳素或睾酮血清水平的正常化与前臂骨密度增加相关（p<0.05）。这些数据表明，男性慢性高泌乳素血症和睾酮缺乏具有有害的、以前未被认识到的性腺外效应，激素浓度正常化后这些效应可能会得到缓解。
