Hugues F C, Le Jeunne C, Boutot F, Lowenstein W, Haas C
Ann Med Interne (Paris). 1986;137(1):41-5.
The authors report the results of a one year study carried out in the Department of Internal Medicine at Laennec Hospital. Out of a total of 1334 hospitalisation, 95 had drug side effects (7.1 p. 100) and 3.5 p. 100 of admissions were directly related to a iatrogenic complication. These complications were more common in women and elderly patients. Sixty-two drugs were implicated: antibiotics (32.6 p. 100), cardiovascular drugs (20 p. 100) including the diuretics (8.4 p. 100), antiinflammatory and antalgic drugs (16.8 p. 100), anticoagulants (8.4 p. 100), neuropsychiatric drugs (7.4 p. 100), oral hypoglycaemic agents (6.3 p. 100)..., 101 side effects were observed: gastro-intestinal (35.6 p. 100) dermato-anaphylactic (19.8 p. 100), cardiovascular (12.9 p. 100), endocrine or metabolic (11.8 p. 100), neuropsychiatric (10.9 p. 100), haematological (5.9 p. 100) and renal (4.2 p. 100). Iatrogenic complications were responsible for the admission to hospital of 47 patients and for 390 days of hospitalisation, costing approximately 380.000 FF.
作者报告了在拉埃内克医院内科进行的一项为期一年的研究结果。在总共1334例住院病例中，95例有药物副作用（每100例中有7.1例），每100例入院病例中有3.5例与医源性并发症直接相关。这些并发症在女性和老年患者中更为常见。涉及62种药物：抗生素（每100例中有32.6例）、心血管药物（每100例中有20例），其中利尿剂（每100例中有8.4例）、抗炎和镇痛药（每100例中有16.8例）、抗凝剂（每100例中有8.4例）、神经精神药物（每100例中有7.4例）、口服降糖药（每100例中有6.3例）……观察到101例副作用：胃肠道（每100例中有35.6例）、皮肤过敏（每100例中有19.8例）、心血管（每100例中有12.9例）、内分泌或代谢（每100例中有11.8例）、神经精神（每100例中有10.9例）、血液学（每100例中有5.9例）和肾脏（每100例中有4.2例）。医源性并发症导致47例患者住院，住院天数达390天，费用约为380000法郎。
