• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

口腔表现对诊断严重苯妥英钠诱导的血小板减少症的意义：1例罕见病例

Significance of Oral Manifestations in the Diagnosis of Severe Phenytoin-Induced Thrombocytopenia: A Rare Case.

作者信息

Gangadaran Vinodh, Balasubramanian Manonmani

机构信息

Department of Dentistry, Kilpauk Medical College and Hospital, Chennai, IND.

Department of Oral and Maxillofacial Surgery, Thai Moogambigai Dental College and Hospital, Chennai, IND.

出版信息

Cureus. 2023 Apr 14;15(4):e37585. doi: 10.7759/cureus.37585. eCollection 2023 Apr.

DOI:10.7759/cureus.37585
PMID:37069839
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10105007/
Abstract

Phenytoin is a commonly used anticonvulsant drug for the prophylaxis of generalized tonic-clonic seizures, partial seizures, and neurosurgery-related seizure prevention. Phenytoin-induced thrombocytopenia is a rare but life-threatening condition. Close monitoring of blood counts may be necessary for patients receiving phenytoin, as delay in diagnosis or withdrawal of the drug can be life-threatening. Clinical manifestations of phenytoin-induced thrombocytopenia are usually reported within one to three weeks after drug initiation. In this article, we report a unique case of drug-induced thrombocytopenia that manifested as multiple hemorrhagic lesions in the oral mucous membrane three months after phenytoin initiation.

摘要

苯妥英钠是一种常用的抗惊厥药物，用于预防全身性强直阵挛性发作、部分性发作以及与神经外科手术相关的癫痫发作预防。苯妥英钠诱导的血小板减少症是一种罕见但危及生命的病症。对于接受苯妥英钠治疗的患者，密切监测血细胞计数可能是必要的，因为诊断延迟或停药可能会危及生命。苯妥英钠诱导的血小板减少症的临床表现通常在开始用药后的一至三周内出现。在本文中，我们报告了一例独特的药物性血小板减少症病例，该病例在开始使用苯妥英钠三个月后表现为口腔黏膜多处出血性病变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ac7/10105007/8d355b0cd86e/cureus-0015-00000037585-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ac7/10105007/ed1d0518d777/cureus-0015-00000037585-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ac7/10105007/928dd20f3a4f/cureus-0015-00000037585-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ac7/10105007/8d355b0cd86e/cureus-0015-00000037585-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ac7/10105007/ed1d0518d777/cureus-0015-00000037585-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ac7/10105007/928dd20f3a4f/cureus-0015-00000037585-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ac7/10105007/8d355b0cd86e/cureus-0015-00000037585-i03.jpg

相似文献

1
Significance of Oral Manifestations in the Diagnosis of Severe Phenytoin-Induced Thrombocytopenia: A Rare Case.口腔表现对诊断严重苯妥英钠诱导的血小板减少症的意义：1例罕见病例
Cureus. 2023 Apr 14;15(4):e37585. doi: 10.7759/cureus.37585. eCollection 2023 Apr.
2
Phenytoin-Induced Severe Thrombocytopenia: A Case Report.苯妥英钠所致严重血小板减少症：一例报告
Cureus. 2024 May 20;16(5):e60669. doi: 10.7759/cureus.60669. eCollection 2024 May.
3
Phenytoin Seizure Prophylaxis Therapy Resulting in Severe Thrombocytopenia After Brain Tumor Debulking Surgery.脑肿瘤减瘤手术后苯妥英钠癫痫预防治疗导致严重血小板减少症
Am J Case Rep. 2020 Jan 30;21:e919828. doi: 10.12659/AJCR.919828.
4
Phenytoin versus valproate monotherapy for partial onset seizures and generalized onset tonic-clonic seizures.苯妥英钠与丙戊酸单药治疗部分性发作和全面性强直阵挛发作的对比
Cochrane Database Syst Rev. 2001(4):CD001769. doi: 10.1002/14651858.CD001769.
5
Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures.苯妥英与丙戊酸单药治疗部分性发作和全面性强直阵挛发作的比较
Cochrane Database Syst Rev. 2013 Aug 23(8):CD001769. doi: 10.1002/14651858.CD001769.pub2.
6
Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review.卡马西平与苯妥英单药治疗癫痫：个体参与者数据回顾
Cochrane Database Syst Rev. 2015 Aug 14(8):CD001911. doi: 10.1002/14651858.CD001911.pub2.
7
New derivative of 1,2,4-triazole-3-thione (TP427) potentiates the anticonvulsant action of valproate, but not that of carbamazepine, phenytoin or phenobarbital in the mouse tonic-clonic seizure model.1,2,4-三唑-3-硫酮（TP427）的新型衍生物增强丙戊酸的抗惊厥作用，但不增强卡马西平、苯妥英或苯巴比妥在小鼠强直-阵挛性惊厥模型中的作用。
Pharmacol Rep. 2019 Apr;71(2):299-305. doi: 10.1016/j.pharep.2019.01.003. Epub 2019 Jan 6.
8
Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalized onset tonic-clonic seizures.苯巴比妥与苯妥英单药治疗部分性发作和全面性强直-阵挛发作的对比
Cochrane Database Syst Rev. 2001(4):CD002217. doi: 10.1002/14651858.CD002217.
9
Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review.丙戊酸钠与苯妥英钠单药治疗癫痫：个体参与者数据回顾
Cochrane Database Syst Rev. 2018 Aug 9;8(8):CD001769. doi: 10.1002/14651858.CD001769.pub4.
10
Oxcarbazepine versus phenytoin monotherapy for epilepsy: an individual participant data review.奥卡西平与苯妥英单药治疗癫痫：个体参与者数据回顾
Cochrane Database Syst Rev. 2018 Oct 23;10(10):CD003615. doi: 10.1002/14651858.CD003615.pub4.

引用本文的文献

1
Phenytoin-Induced Severe Thrombocytopenia: A Case Report.苯妥英钠所致严重血小板减少症：一例报告
Cureus. 2024 May 20;16(5):e60669. doi: 10.7759/cureus.60669. eCollection 2024 May.

本文引用的文献

1
Pathophysiology and Diagnosis of Drug-Induced Immune Thrombocytopenia.药物性免疫性血小板减少症的病理生理学与诊断
J Clin Med. 2020 Jul 13;9(7):2212. doi: 10.3390/jcm9072212.
2
Phenytoin: 80 years young, from epilepsy to breast cancer, a remarkable molecule with multiple modes of action.苯妥英：80 年历史的老药，从癫痫到乳腺癌，具有多种作用模式的非凡分子。
J Neurol. 2017 Aug;264(8):1617-1621. doi: 10.1007/s00415-017-8391-5. Epub 2017 Jan 12.
3
Drug-induced immune thrombocytopenia: pathogenesis, diagnosis, and management.药物性免疫性血小板减少症：发病机制、诊断与管理
J Thromb Haemost. 2009 Jun;7(6):911-8. doi: 10.1111/j.1538-7836.2009.03360.x. Epub 2009 Apr 2.
4
Drug-induced thrombocytopenia.药物性血小板减少症
Arch Pathol Lab Med. 2009 Feb;133(2):309-14. doi: 10.5858/133.2.309.
5
Fatal phenytoin-induced thrombocytopaenia in a neurosurgical patient.一名神经外科患者发生致命性苯妥英钠所致血小板减少症。
Eur J Anaesthesiol. 2007 Oct;24(10):897-8. doi: 10.1017/s0265021507000750.
6
Drug-induced thrombocytopenia: a systematic review of published case reports.药物性血小板减少症：已发表病例报告的系统评价
Ann Intern Med. 1998 Dec 1;129(11):886-90. doi: 10.7326/0003-4819-129-11_part_1-199812010-00009.
7
Antiepileptics and blood dyscrasias: a cohort study.抗癫痫药物与血液系统疾病：一项队列研究。
Pharmacotherapy. 1998 Nov-Dec;18(6):1277-83.
8
Drug-induced thrombocytopenia: clinical data on 309 cases and the effect of corticosteroid therapy.药物性血小板减少症：309例临床资料及糖皮质激素治疗效果
Eur J Clin Pharmacol. 1997;52(3):183-9. doi: 10.1007/s002280050272.
9
Landmark article Sept 17, 1938: Sodium diphenyl hydantoinate in the treatment of convulsive disorders. By H. Houston Merritt and Tracy J. Putnam.里程碑式文章，1938年9月17日：苯妥英钠治疗惊厥性疾病。作者：H. 休斯顿·梅里特和特雷西·J. 普特南。
JAMA. 1984 Feb 24;251(8):1062-7. doi: 10.1001/jama.251.8.1062.
10
Phenytoin-induced thrombocytopenia.
Pediatr Neurol. 1986 Mar-Apr;2(2):99-101. doi: 10.1016/0887-8994(86)90064-0.