Zhao Tong, Wang Yuejun, Zhou Deqing, Zhang Weike
Department of Oncology, The Eighth People's Hospital of Jinan, No. 68, Xinxing Road, Gangcheng District, Jinan 271104, P.R. China.
Department of Medical Administration, Jinan Gangcheng District Health Bureau, Jinan 270016, P.R. China.
Open Life Sci. 2023 Apr 12;18(1):20220590. doi: 10.1515/biol-2022-0590. eCollection 2023.
We investigated the effect of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) on lymphocytes and white blood cells of patients with malignant tumors. After PEG-rhG-CSF treatment, the count of lymphocytes increased in 66 cases, remained unchanged in 2 cases, and decreased in 20 cases. The difference in lymphocyte count before and after treatment was statistically significant ( < 0.001). White blood cell changes were positively correlated with lymphocyte changes ( = 0.36, = 0.001). In the subgroup with increased white blood cells ( = 80), there were 62 cases with increased lymphocytes, 1 case with unchanged lymphocytes, and 17 cases with decreased lymphocytes after PEG-rhG-CSF treatment. There was significant difference in the count of lymphocytes and white blood cells ( < 0.001). In the subgroup with 6 mg of PEG-rhG-CSF ( = 66) and the subgroup with 3 mg of PEG-rhG-CSF ( = 22), the changes of white blood cell and lymphocyte counts before and after treatment were statistically significant ( < 0.001). The two were positively correlated in the 6 mg PEG-rhG-CSF subgroup, with correlation coefficient = 0.34 ( = 0.002). PEG-rhG-CSF can increase the count of lymphocytes and white blood cells in patients with malignant tumors, and the increase of lymphocytes is positively correlated with the increase of white blood cells.
我们研究了聚乙二醇化重组人粒细胞集落刺激因子（PEG-rhG-CSF）对恶性肿瘤患者淋巴细胞和白细胞的影响。PEG-rhG-CSF治疗后，66例患者淋巴细胞计数增加，2例不变，20例减少。治疗前后淋巴细胞计数差异有统计学意义（<0.001）。白细胞变化与淋巴细胞变化呈正相关（=0.36，=0.001）。在白细胞增加的亚组（=80）中，PEG-rhG-CSF治疗后有62例淋巴细胞增加，1例淋巴细胞不变，17例淋巴细胞减少。淋巴细胞和白细胞计数有显著差异（<0.001）。在PEG-rhG-CSF 6mg亚组（=66）和PEG-rhG-CSF 3mg亚组（=22）中，治疗前后白细胞和淋巴细胞计数变化有统计学意义（<0.001）。在PEG-rhG-CSF 6mg亚组中两者呈正相关，相关系数=0.34（=0.002）。PEG-rhG-CSF可增加恶性肿瘤患者的淋巴细胞和白细胞计数，且淋巴细胞增加与白细胞增加呈正相关。
