Department of Human Physiology and Pathophysiology, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Department of Internal Diseases with Clinic, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Eur J Neurosci. 2023 May;57(10):1642-1656. doi: 10.1111/ejn.15991. Epub 2023 Apr 26.
This review focuses on receptor for advanced glycation endproducts/diaphonous related formin 1 (RAGE/Diaph1) interaction as a modulator of actin cytoskeleton dynamics in peripheral nervous system (PNS) in diabetes. Deciphering the complex molecular interactions between RAGE and Diaph1 is crucial in expanding our understanding of diabetic length dependent neuropathy (DLDN). DLDN is a common neurological disorder in patients with diabetes. It is well known that actin cytoskeletal homeostasis is disturbed during DLDN. Thus, we review the current status of knowledge about RAGE/Diaph1 impact on actin cytoskeletal malfunctions in PNS and DLDN progression in diabetes. We also survey studies about small molecules that may block RAGE/Diaph1 axis and thus inhibit the progression of DLDN. Finally, we explore examples of cytoskeletal long-non coding RNAs (lncRNAs) currently unrelated to DLDN, to discuss their potential role in this disease. Most recent studies indicated that lncRNAs have a great potential in many research areas, including RAGE/Diaph1 axis as well as DLDN. Altogether, this review is aimed at giving us an insight into the involvement of cytoskeletal lncRNAs in DLDN.
这篇综述主要关注晚期糖基化终产物受体/分裂相关formin1（RAGE/Diaph1）相互作用作为糖尿病周围神经系统（PNS）中肌动蛋白细胞骨架动态的调节剂。解析 RAGE 和 Diaph1 之间复杂的分子相互作用对于扩展我们对糖尿病长度依赖性神经病（DLDN）的理解至关重要。DLDN 是糖尿病患者常见的神经紊乱疾病。众所周知，在 DLDN 期间，肌动蛋白细胞骨架的动态平衡受到干扰。因此，我们综述了目前关于 RAGE/Diaph1 对 PNS 中肌动蛋白细胞骨架功能障碍和糖尿病中 DLDN 进展影响的知识现状。我们还调查了可能阻断 RAGE/Diaph1 轴从而抑制 DLDN 进展的小分子的研究。最后，我们探讨了一些目前与 DLDN 无关的细胞骨架长非编码 RNA（lncRNA）的例子，以讨论它们在这种疾病中的潜在作用。最近的研究表明，lncRNA 在许多研究领域具有很大的潜力，包括 RAGE/Diaph1 轴和 DLDN。总的来说，这篇综述旨在让我们深入了解细胞骨架 lncRNA 如何参与 DLDN。
