Medical College, University of Sulaimani, Sulaymaniyah, Iraq.
Eur Rev Med Pharmacol Sci. 2023 Apr;27(7):3003-3008. doi: 10.26355/eurrev_202304_31933.
Thyroid disease is the second most commonly affected disease in childbearing women, after diabetes, and thyroid autoimmunity in pregnancy has been connected with adverse pregnancy outcomes such as miscarriage, recurrent miscarriage, preterm birth, and low IQ. The study seeks to determine the correlation between anti-thyroid peroxidase antibodies and unexplained recurrent miscarriage.
124 women were included in this case-control study, divided into 62 women who have experienced unexplained recurrent miscarriages and 62 healthy women without a history of miscarriage. Screening for TSH and anti-TPO antibody were done for both groups.
The prevalence rate of positive anti-TPO antibody in women with recurrent miscarriage was 19.4%, while in women without miscarriage was 6.5% (which is considerably higher in cases than in women without recurrent miscarriage with a p-value of 0.03 and an odd ratio of 3.48 (95% CI; 1.06-11.48).
A statistically significant relationship between anti-TPO antibodies and recurrent miscarriage has been detected. We recommend screening for TSH and thyroid antibodies for women with recurrent miscarriages and further studies on the effect of levothyroxine therapy for euthyroid women with antibody positive.
甲状腺疾病是仅次于糖尿病的育龄妇女第二大高发疾病，而妊娠期间的甲状腺自身免疫与流产、反复流产、早产和低智商等不良妊娠结局有关。本研究旨在探讨抗甲状腺过氧化物酶抗体与不明原因复发性流产之间的相关性。
本病例对照研究纳入了 124 名女性，分为 62 名经历过不明原因复发性流产的女性和 62 名无流产史的健康女性。对两组均进行 TSH 和抗 TPO 抗体筛查。
复发性流产女性中抗 TPO 抗体阳性率为 19.4%，而无流产女性中为 6.5%（流产组明显更高，p 值为 0.03，优势比为 3.48（95%CI；1.06-11.48）。
抗 TPO 抗体与复发性流产之间存在统计学显著关系。我们建议对复发性流产的女性进行 TSH 和甲状腺抗体筛查，并进一步研究甲状腺功能正常的抗体阳性女性应用左甲状腺素治疗的效果。
