Umeda T, Takada N, Hodaka E, Endoh F, Ishii T
Gan To Kagaku Ryoho. 1986 May;13(5):1857-61.
A total of 31 patients with malignant bone and soft tissue tumors were evaluated for toxic effects after receiving cisplatin (104 courses) at doses of 2.0-3.0 mg/kg with aggressive hydration. Nausea was common and in 86% of cisplatin courses severe vomiting was observed. Nephrotoxicity was observed in less than 10% of all courses but ototoxicity, especially tinnitis, developed in 5 of 6 patients whose total doses of cisplatin were over 500mg, and one of them showed hearing disorder in the upper frequency above 5,000 Hz. There were no other toxic effects such as severe myelosuppression, allergic reaction or peripheral neuropathy.
共有31例恶性骨与软组织肿瘤患者接受了剂量为2.0 - 3.0mg/kg的顺铂治疗（共104个疗程），同时进行积极水化，并对其毒性作用进行评估。恶心很常见，在86%的顺铂疗程中观察到严重呕吐。在所有疗程中，肾毒性的发生率低于10%，但在6例顺铂总剂量超过500mg的患者中，有5例出现耳毒性，尤其是耳鸣，其中1例在5000Hz以上的高频出现听力障碍。未观察到其他毒性作用，如严重骨髓抑制、过敏反应或周围神经病变。
